5YYF

Crystal structure of AF9 YEATS domain in complex with a peptide inhibitor "PHQ-H3(Q5-K9)" modified at K9 with 2-furancarboyl group

Summary for 5YYF

• Entry DOI: 10.2210/pdb5yyf/pdb
• Related PRD ID: PRD_002284
• Descriptor: Protein AF-9, Peptide inhibitor PHQ-H3(Q5-K9), SULFATE ION, ... (5 entities in total)
• Functional Keywords: yeats domain, complex, inhibitor, 2-furancarboyl group, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 35245.24

Authors

Li, Y.,Li, H. (deposition date: 2017-12-09, release date: 2018-11-07, Last modification date: 2023-11-22)

• Primary citation: Li, X.,Li, X.M.,Jiang, Y.,Liu, Z.,Cui, Y.,Fung, K.Y.,van der Beelen, S.H.E.,Tian, G.,Wan, L.,Shi, X.,Allis, C.D.,Li, H.,Li, Y.,Li, X.D.; Structure-guided development of YEATS domain inhibitors by targeting pi-pi-pi stacking.; Nat. Chem. Biol., 14:1140-1149, 2018; PubMed: 30374167; DOI: 10.1038/s41589-018-0144-y

Experimental method

X-RAY DIFFRACTION (1.903 Å)