5YYF
Crystal structure of AF9 YEATS domain in complex with a peptide inhibitor "PHQ-H3(Q5-K9)" modified at K9 with 2-furancarboyl group
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | ARG16 |
| A | MET33 |
| A | PHE35 |
| A | ARG37 |
| A | HOH356 |
| A | HOH366 |
| A | HOH389 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | ARG99 |
| A | HIS54 |
| A | PRO84 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue FOA B 101 |
| Chain | Residue |
| A | PHE28 |
| A | SER58 |
| A | PHE59 |
| A | SER76 |
| A | GLY77 |
| A | TYR78 |
| A | ALA79 |
| A | HOH334 |
| B | LYS9 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 201 |
| Chain | Residue |
| C | PHE35 |
| C | ARG37 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide PHQ D 4 and GLN D 5 |
| Chain | Residue |
| A | ARG99 |
| C | PHE105 |
| C | LEU106 |
| C | HIS107 |
| C | LEU108 |
| C | HIS111 |
| C | HOH330 |
| D | THR6 |
| D | ARG8 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide LYS D 9 and NH2 D 10 |
| Chain | Residue |
| C | HIS56 |
| C | SER58 |
| C | PHE59 |
| C | GLY80 |
| C | PHE81 |
| D | ARG8 |
| D | FOA101 |
| D | HOH202 |
| D | HOH206 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide FOA D 101 and LYS D 9 |
| Chain | Residue |
| C | PHE28 |
| C | SER58 |
| C | PHE59 |
| C | SER76 |
| C | GLY77 |
| C | TYR78 |
| C | ALA79 |
| C | GLY80 |
| C | PHE81 |
| D | ARG8 |
| D | NH210 |
| D | HOH202 |
| D | HOH204 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 274 |
| Details | Domain: {"description":"YEATS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00376","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"Histone H3K9cr binding","evidences":[{"source":"PubMed","id":"27105114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30385749","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5HJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MIL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MIM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Histone H3K9cr binding","evidences":[{"source":"PubMed","id":"27105114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30385749","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5HJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MIL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MIM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
