5YYF
Crystal structure of AF9 YEATS domain in complex with a peptide inhibitor "PHQ-H3(Q5-K9)" modified at K9 with 2-furancarboyl group
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Protein AF-9 | polymer | 141 | 16611.2 | 2 | UniProt (P42568) Pfam (PF03366) | Homo sapiens (Human) | ALL1-fused gene from chromosome 9 protein,Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein,YEATS domain-containing protein 3 |
| 2 | B, D (B, D) | Peptide inhibitor PHQ-H3(Q5-K9) | polymer | 7 | 755.3 | 2 | BIRD (PRD_002284) | Homo sapiens | |
| 3 | E, F, H (A, C) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | G, I (B, D) | 2-FUROIC ACID | non-polymer | 112.1 | 2 | BIRD (PRD_002284) Chemie (FOA) | |||
| 5 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 278 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 138 (UniProt: P42568)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 34732.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 512.4 | |
| All* | Total formula weight | 35245.2 |
