3Q4R
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5F8E
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![BU of 5f8e by Molmil](/molmil-images/mine/5f8e) | Rv2258c-SAH | 分子名称: | Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Im, H.N, Suh, S.W. | 登録日 | 2015-12-09 | 公開日 | 2016-06-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structure of Rv2258c from Mycobacterium tuberculosis H37Rv, an S-adenosyl-l-methionine-dependent methyltransferase J.Struct.Biol., 193, 2016
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5F8F
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![BU of 5f8f by Molmil](/molmil-images/mine/5f8f) | Rv2258c-SFG | 分子名称: | GLYCEROL, Methyltransferase, SINEFUNGIN | 著者 | Im, H.N, Suh, S.W. | 登録日 | 2015-12-09 | 公開日 | 2016-06-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of Rv2258c from Mycobacterium tuberculosis H37Rv, an S-adenosyl-l-methionine-dependent methyltransferase J.Struct.Biol., 193, 2016
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5F8C
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![BU of 5f8c by Molmil](/molmil-images/mine/5f8c) | Rv2258c-unbound | 分子名称: | GLYCEROL, Methyltransferase | 著者 | Im, H.N, Suh, S.W. | 登録日 | 2015-12-09 | 公開日 | 2016-06-29 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Crystal structure of Rv2258c from Mycobacterium tuberculosis H37Rv, an S-adenosyl-l-methionine-dependent methyltransferase J.Struct.Biol., 193, 2016
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5GHV
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![BU of 5ghv by Molmil](/molmil-images/mine/5ghv) | Crystal structure of an inhibitor-bound Syk | 分子名称: | 1-({1-[2-({3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]-4-methyl-1H-pyrrol-3-yl}methyl)azetidin-3-ol, Tyrosine-protein kinase SYK | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | 登録日 | 2016-06-20 | 公開日 | 2016-07-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs Febs J., 283, 2016
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6HTF
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7JTP
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![BU of 7jtp by Molmil](/molmil-images/mine/7jtp) | Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | 分子名称: | Elongin-B, Elongin-C, GLYCEROL, ... | 著者 | Kottur, J, Jain, R, Aggarwal, A.K. | 登録日 | 2020-08-18 | 公開日 | 2021-10-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
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7JTO
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![BU of 7jto by Molmil](/molmil-images/mine/7jto) | Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | 分子名称: | 1,2-ETHANEDIOL, 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, Elongin-B, ... | 著者 | Kottur, J, Jain, R, Aggarwal, A.K. | 登録日 | 2020-08-18 | 公開日 | 2021-10-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
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6AFP
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![BU of 6afp by Molmil](/molmil-images/mine/6afp) | Crystal structure of class A b-lactamase, PenL, variant Asn136Asp, from Burkholderia thailandensis, in complex with ceftazidime-like boronic acid | 分子名称: | ACETATE ION, Beta-lactamase, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE | 著者 | Cao, T.-P, Choi, J.M, Lee, S.H. | 登録日 | 2018-08-08 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.398 Å) | 主引用文献 | Non-catalytic-Region Mutations Conferring Transition of Class A beta-Lactamases Into ESBLs. Front Mol Biosci, 2020
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6AFM
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6AFO
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6AFN
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![BU of 6afn by Molmil](/molmil-images/mine/6afn) | Crystal structure of class A b-lactamase, PenL, variant Cys69Tyr, from Burkholderia thailandensis, in complex with ceftazidime-like boronic acid | 分子名称: | Beta-lactamase, GLYCEROL, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE | 著者 | Cao, T.-P, Choi, J.M, Lee, S.H. | 登録日 | 2018-08-08 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Non-catalytic-Region Mutations Conferring Transition of Class A beta-Lactamases Into ESBLs. Front Mol Biosci, 2020
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7UX9
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![BU of 7ux9 by Molmil](/molmil-images/mine/7ux9) | Arabidopsis DDM1 bound to nucleosome (H2A.W, H2B, H3.3, H4, with 147 bp DNA) | 分子名称: | ATP-dependent DNA helicase DDM1, DNA (antisense strand), DNA (sense strand), ... | 著者 | Ipsaro, J.J, Adams, D.W, Joshua-Tor, L. | 登録日 | 2022-05-05 | 公開日 | 2023-08-09 | 最終更新日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation. Cell, 186, 2023
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5ENO
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![BU of 5eno by Molmil](/molmil-images/mine/5eno) | MBX2319 bound structure of bacterial efflux pump. | 分子名称: | 3,3-dimethyl-8-morpholin-4-yl-6-(2-phenylethylsulfanyl)-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | 登録日 | 2015-11-09 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc.Natl.Acad.Sci.USA, 113, 2016
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5ENS
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![BU of 5ens by Molmil](/molmil-images/mine/5ens) | Rhodamine bound structure of bacterial efflux pump. | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, RHODAMINE 6G | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | 登録日 | 2015-11-09 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc.Natl.Acad.Sci.USA, 113, 2016
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5ENP
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![BU of 5enp by Molmil](/molmil-images/mine/5enp) | MBX2931 bound structure of bacterial efflux pump. | 分子名称: | 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | 登録日 | 2015-11-09 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc.Natl.Acad.Sci.USA, 113, 2016
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5ENQ
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![BU of 5enq by Molmil](/molmil-images/mine/5enq) | MBX3132 bound structure of bacterial efflux pump. | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, ~{N}-[4-[2-[[5-cyano-8-[(2~{S},6~{R})-2,6-dimethylmorpholin-4-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridin-6-yl]sulfanyl]ethyl]phenyl]ethanamide | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | 登録日 | 2015-11-09 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc.Natl.Acad.Sci.USA, 113, 2016
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5ENT
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![BU of 5ent by Molmil](/molmil-images/mine/5ent) | Minocycline bound structure of bacterial efflux pump. | 分子名称: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, DARPin, DI(HYDROXYETHYL)ETHER, ... | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | 登録日 | 2015-11-09 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc.Natl.Acad.Sci.USA, 113, 2016
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5ENR
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![BU of 5enr by Molmil](/molmil-images/mine/5enr) | MBX3135 bound structure of bacterial efflux pump. | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, ~{N}-[4-[2-[[5-cyano-8-[(2~{S},6~{S})-2,6-dimethylmorpholin-4-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridin-6-yl]sulfanyl]ethyl]phenyl]prop-2-enamide | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | 登録日 | 2015-11-09 | 公開日 | 2016-04-06 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc.Natl.Acad.Sci.USA, 113, 2016
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5EN5
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![BU of 5en5 by Molmil](/molmil-images/mine/5en5) | Apo structure of bacterial efflux pump. | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB | 著者 | Sjuts, H, Ornik, A.R, Pos, K.M. | 登録日 | 2015-11-09 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives. Proc.Natl.Acad.Sci.USA, 113, 2016
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5GTO
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![BU of 5gto by Molmil](/molmil-images/mine/5gto) | Human PPARgamma ligand binding dmain complexed with S35 | 分子名称: | 2-[4-[5-[(1~{S})-1-[(3,5-dimethoxyphenyl)carbamoyl-(phenylmethyl)carbamoyl]oxypropyl]-1,2-oxazol-3-yl]phenoxy]-2-methyl-propanoic acid, GLYCEROL, MYRISTIC ACID, ... | 著者 | Jang, J.Y, Suh, S.W. | 登録日 | 2016-08-22 | 公開日 | 2017-07-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for differential activities of enantiomeric PPAR gamma agonists: Binding of S35 to the alternate site. Biochim. Biophys. Acta, 1865, 2017
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5GTP
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4PKL
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![BU of 4pkl by Molmil](/molmil-images/mine/4pkl) | Bromodomain of Trypanosoma brucei BDF2 With IBET-151 | 分子名称: | 7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE, Bromodomain factor 2, CHLORIDE ION, ... | 著者 | Debler, E.W. | 登録日 | 2014-05-15 | 公開日 | 2015-11-18 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.251 Å) | 主引用文献 | Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome. Plos Biol., 13, 2015
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5XIX
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6PY2
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![BU of 6py2 by Molmil](/molmil-images/mine/6py2) | HLA-TCR complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DQ2.2-glut-L1, GLYCEROL, ... | 著者 | Ting, Y.T, Peteren, J, Reid, H.H, Rossjohn, J. | 登録日 | 2019-07-28 | 公開日 | 2020-01-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.82543421 Å) | 主引用文献 | A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease. Proc.Natl.Acad.Sci.USA, 117, 2020
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