6AFN

Crystal structure of class A b-lactamase, PenL, variant Cys69Tyr, from Burkholderia thailandensis, in complex with ceftazidime-like boronic acid

Summary for 6AFN

Entry DOI	10.2210/pdb6afn/pdb
Descriptor	Beta-lactamase, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, GLYCEROL, ... (4 entities in total)
Functional Keywords	extended-spectrum beta-lactam, cys69tyr, penl, burkhodelria, ceftazidime-like boronic acid hydrolase, hydrolase
Biological source	Burkholderia thailandensis
Total number of polymer chains	1
Total formula weight	29159.71
Authors	Cao, T.-P.,Choi, J.M.,Lee, S.H. (deposition date: 2018-08-08, release date: 2020-01-15, Last modification date: 2023-11-22)
Primary citation	Cao, T.-P.,Yi, H.,Dhanasingh, I.,Ghosh, S.,Choi, J.M.,Lee, K.H.,Ryu, S.,Kim, H.S.,Lee, S.H. Non-catalytic-Region Mutations Conferring Transition of Class A beta-Lactamases Into ESBLs. Front Mol Biosci, 2020 Cited by DOI: 10.3389/fmolb.2020.598998 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation