4PKL

Bromodomain of Trypanosoma brucei BDF2 With IBET-151

Summary for 4PKL

• Entry DOI: 10.2210/pdb4pkl/pdb
• Descriptor: Bromodomain factor 2, 7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE, PHOSPHATE ION, ... (7 entities in total)
• Functional Keywords: signaling protein, inhibitor, histone, epigenetic reader, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Trypanosoma brucei brucei
• Total number of polymer chains: 2
• Total formula weight: 28131.84

Authors

Debler, E.W. (deposition date: 2014-05-15, release date: 2015-11-18, Last modification date: 2023-12-27)

• Primary citation: Schulz, D.,Mugnier, M.R.,Paulsen, E.M.,Kim, H.S.,Chung, C.W.,Tough, D.F.,Rioja, I.,Prinjha, R.K.,Papavasiliou, F.N.,Debler, E.W.; Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome.; Plos Biol., 13:e1002316-e1002316, 2015; PubMed: 26646171; DOI: 10.1371/journal.pbio.1002316

Experimental method

X-RAY DIFFRACTION (1.251 Å)