4PKL
Bromodomain of Trypanosoma brucei BDF2 With IBET-151
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bromodomain factor 2 | polymer | 119 | 13500.1 | 2 | UniProt (Q38AM1) Pfam (PF00439) | Trypanosoma brucei brucei | |
| 2 | C, G (A, B) | 7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE | non-polymer | 415.4 | 2 | Chemie (1GH) | |||
| 3 | D (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | E, H (A, B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 5 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | I (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | J, K (A, B) | water | water | 18.0 | 274 | Chemie (HOH) |
Sequence modifications
A, B: 9 - 123 (UniProt: Q38AM1)
| PDB | External Database | Details |
|---|---|---|
| Gly 5 | - | expression tag |
| Pro 6 | - | expression tag |
| His 7 | - | expression tag |
| Met 8 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27000.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1131.6 | |
| All* | Total formula weight | 28131.8 |
