5ENP

MBX2931 bound structure of bacterial efflux pump.

Summary for 5ENP

• Entry DOI: 10.2210/pdb5enp/pdb
• Descriptor: Multidrug efflux pump subunit AcrB,Multidrug efflux pump subunit AcrB, DARPin, 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, ... (4 entities in total)
• Functional Keywords: efflux pump, transport protein
• Biological source: Escherichia coli (strain K12); More
• Cellular location: Cell inner membrane ; Multi- pass membrane protein : P31224
• Total number of polymer chains: 6
• Total formula weight: 252701.36

Authors

Sjuts, H.,Ornik, A.R.,Pos, K.M. (deposition date: 2015-11-09, release date: 2016-04-06, Last modification date: 2024-01-10)

• Primary citation: Sjuts, H.,Vargiu, A.V.,Kwasny, S.M.,Nguyen, S.T.,Kim, H.S.,Ding, X.,Ornik, A.R.,Ruggerone, P.,Bowlin, T.L.,Nikaido, H.,Pos, K.M.,Opperman, T.J.; Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.; Proc.Natl.Acad.Sci.USA, 113:3509-3514, 2016; PubMed: 26976576; DOI: 10.1073/pnas.1602472113

Experimental method

X-RAY DIFFRACTION (1.9 Å)