2J5E
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2JKM
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![BU of 2jkm by Molmil](/molmil-images/mine/2jkm) | Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor | 分子名称: | 2-{[5-CHLORO-2-({(1E,4R)-2-METHOXY-4-[(3R)-3-(METHYLAMINO)PYRROLIDIN-1-YL]CYCLOHEXA-2,5-DIEN-1-YLIDENE}AMINO)PYRIMIDIN-4-YL]AMINO}-N-(1-METHYLETHYL)BENZENESULFONAMIDE, FOCAL ADHESION KINASE 1 | 著者 | Lietha, D, Eck, M.J. | 登録日 | 2008-08-28 | 公開日 | 2008-09-09 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Crystal Structures of the Fak Kinase in Complex with Tae226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical Dfg Conformation. Plos One, 3, 2008
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2JKO
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3ZDT
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![BU of 3zdt by Molmil](/molmil-images/mine/3zdt) | Crystal structure of basic patch mutant FAK FERM domain FAK31- 405 K216A, K218A, R221A, K222A | 分子名称: | FOCAL ADHESION KINASE 1 | 著者 | Goni, G.M, Epifano, C, Boskovic, J, Camacho-Artacho, M, Zhou, J, Martin, M.T, Eck, M.J, Kremer, L, Graeter, F, Gervasio, F.L, Perez-Moreno, M, Lietha, D. | 登録日 | 2012-11-30 | 公開日 | 2012-12-12 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Phosphatidylinositol 4,5-Bisphosphate Triggers Activation of Focal Adhesion Kinase by Inducing Clustering and Conformational Changes. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CYE
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![BU of 4cye by Molmil](/molmil-images/mine/4cye) | Crystal structure of avian FAK FERM domain FAK31-405 at 3.2A | 分子名称: | FOCAL ADHESION KINASE 1 | 著者 | Goni, G.M, Epifano, C, Boskovic, J, Camacho-Artacho, M, Zhou, J, Martin, M.T, Eck, M.J, Kremer, L, Graeter, F, Gervasio, F.L, Perez-Moreno, M, Lietha, D. | 登録日 | 2014-04-10 | 公開日 | 2014-04-23 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Phosphatidylinositol 4,5-Bisphosphate Triggers Activation of Focal Adhesion Kinase by Inducing Clustering and Conformational Changes. Proc.Natl.Acad.Sci.USA, 111, 2014
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7JXL
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![BU of 7jxl by Molmil](/molmil-images/mine/7jxl) | EGFR kinase (T790M/V948R) in complex with AZ5104 | 分子名称: | Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide | 著者 | Beyett, T.S, Eck, M.J. | 登録日 | 2020-08-27 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors Nat Commun, 13, 2022
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7JXP
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![BU of 7jxp by Molmil](/molmil-images/mine/7jxp) | EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-04-125-02 | 分子名称: | (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ... | 著者 | Beyett, T.S, Eck, M.J. | 登録日 | 2020-08-27 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors Nat Commun, 13, 2022
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7JXM
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![BU of 7jxm by Molmil](/molmil-images/mine/7jxm) | EGFR kinase (T790M/V948R) in complex with osimertinib and EAI045 | 分子名称: | (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ... | 著者 | Beyett, T.S, Eck, M.J. | 登録日 | 2020-08-27 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.192 Å) | 主引用文献 | Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors Nat Commun, 13, 2022
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7K1I
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![BU of 7k1i by Molmil](/molmil-images/mine/7k1i) | EGFR kinase (L858R/V948R) in complex with allosteric inhibitor JBJ-09-063 | 分子名称: | (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ... | 著者 | Beyett, T.S, Eck, M.J. | 登録日 | 2020-09-07 | 公開日 | 2021-09-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.202 Å) | 主引用文献 | Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors Nat Commun, 13, 2022
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7JXK
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![BU of 7jxk by Molmil](/molmil-images/mine/7jxk) | EGFR kinase (T790M/V948R) in complex with PF-06747775 and JBJ-04-125-02 | 分子名称: | (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ... | 著者 | Beyett, T.S, Eck, M.J. | 登録日 | 2020-08-27 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors Nat Commun, 13, 2022
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7K1H
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![BU of 7k1h by Molmil](/molmil-images/mine/7k1h) | EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063 | 分子名称: | (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | 著者 | Beyett, T.S, Eck, M.J. | 登録日 | 2020-09-07 | 公開日 | 2021-09-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | 主引用文献 | Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors Nat Commun, 13, 2022
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7JXW
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![BU of 7jxw by Molmil](/molmil-images/mine/7jxw) | EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-09-063 | 分子名称: | (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | 著者 | Beyett, T.S, Eck, M.J. | 登録日 | 2020-08-28 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors Nat Commun, 13, 2022
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7JXI
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![BU of 7jxi by Molmil](/molmil-images/mine/7jxi) | EGFR kinase (T790M/V948R) in complex with PF-06747775 | 分子名称: | Epidermal growth factor receptor, N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl}pyrrolidin-3-yl]propanamide | 著者 | Beyett, T.S, Eck, M.J. | 登録日 | 2020-08-27 | 公開日 | 2021-09-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors Nat Commun, 13, 2022
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1M27
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![BU of 1m27 by Molmil](/molmil-images/mine/1m27) | Crystal structure of SAP/FynSH3/SLAM ternary complex | 分子名称: | CITRATE ANION, Proto-oncogene tyrosine-protein kinase FYN, SH2 domain protein 1A, ... | 著者 | Chan, B, Griesbach, J, Song, H.K, Poy, F, Terhorst, C, Eck, M.J. | 登録日 | 2002-06-21 | 公開日 | 2003-05-06 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | SAP couples Fyn to SLAM immune receptors. NAT.CELL BIOL., 5, 2003
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1L3E
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![BU of 1l3e by Molmil](/molmil-images/mine/1l3e) | NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex | 分子名称: | ZINC ION, hypoxia inducible factor-1 alpha subunit, p300 protein | 著者 | Freedman, S.J, Sun, Z.J, Poy, F, Kung, A.L, Livingston, D.M, Wagner, G, Eck, M.J. | 登録日 | 2002-02-26 | 公開日 | 2002-04-24 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc.Natl.Acad.Sci.USA, 99, 2002
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1NHL
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1KSW
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![BU of 1ksw by Molmil](/molmil-images/mine/1ksw) | Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP | 分子名称: | N6-BENZYL ADENOSINE-5'-DIPHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | 著者 | Witucki, L.A, Huang, X, Shah, K, Liu, Y, Kyin, S, Eck, M.J, Shokat, K.M. | 登録日 | 2002-01-14 | 公開日 | 2002-02-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem.Biol., 9, 2002
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1NU2
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![BU of 1nu2 by Molmil](/molmil-images/mine/1nu2) | Crystal structure of the murine Disabled-1 (Dab1) PTB domain-ApoER2 peptide-PI-4,5P2 ternary complex | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Disabled homolog 1, peptide derived from murine Apolipoprotein E Receptor-2 | 著者 | Stolt, P.C, Jeon, H, Song, H.K, Herz, J, Eck, M.J, Blacklow, S.C. | 登録日 | 2003-01-30 | 公開日 | 2003-04-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Origins of Peptide Selectivity and Phosphoinositide Binding Revealed by Structures of Disabled-1 PTB Domain Complexes Structure, 11, 2003
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3O0Z
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3OKQ
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3ONX
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1LCJ
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1LCK
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1TCE
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![BU of 1tce by Molmil](/molmil-images/mine/1tce) | SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM THE T-CELL RECEPTOR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | PHOSPHOPEPTIDE OF THE ZETA CHAIN OF T CELL RECEPTOR, SHC | 著者 | Zhou, M.-M, Meadows, R.P, Logan, T.M, Yoon, H.S, Wade, W.R, Ravichandran, K.S, Burakoff, S.J, Feisk, S.W. | 登録日 | 1996-03-27 | 公開日 | 1997-05-15 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor. Proc.Natl.Acad.Sci.USA, 92, 1995
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4TSV
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