7W1S
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![BU of 7w1s by Molmil](/molmil-images/mine/7w1s) | Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-007 | 分子名称: | Nanobody Nb-007, Spike protein S1 | 著者 | Yang, J, Lin, S, Sun, H.L, Lu, G.W. | 登録日 | 2021-11-20 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding. Front Immunol, 13, 2022
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1P5J
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5C9C
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![BU of 5c9c by Molmil](/molmil-images/mine/5c9c) | CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND | 分子名称: | 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea, CHLORIDE ION, Serine/threonine-protein kinase B-raf | 著者 | Edwards, T, Abendroth, J, Chun, L. | 登録日 | 2015-06-26 | 公開日 | 2015-07-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers. Cancer Cell, 28, 2015
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6EFJ
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![BU of 6efj by Molmil](/molmil-images/mine/6efj) | Crystal structure of NDM-1 with compound 9 | 分子名称: | (2R)-2-phenyl-2-(phenylamino)-N-(1H-tetrazol-5-yl)acetamide, Metallo-beta-lactamase type 2, ZINC ION | 著者 | Akhtar, A, Chen, Y. | 登録日 | 2018-08-16 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery. Acs Infect Dis., 5, 2019
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6WHC
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![BU of 6whc by Molmil](/molmil-images/mine/6whc) | CryoEM Structure of the glucagon receptor with a dual-agonist peptide | 分子名称: | Dual-agonist peptide, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Belousoff, M.J, Sexton, P, Danev, R. | 登録日 | 2020-04-07 | 公開日 | 2020-05-27 | 最終更新日 | 2020-07-22 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide. J.Biol.Chem., 295, 2020
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8KI4
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![BU of 8ki4 by Molmil](/molmil-images/mine/8ki4) | Crystal structure of human HSP90 in intermediate state | 分子名称: | 1,2-ETHANEDIOL, Heat shock protein HSP 90-alpha | 著者 | Xu, C, Zhang, X.L, Bai, F. | 登録日 | 2023-08-22 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Accurate Characterization of Binding Kinetics and Allosteric Mechanisms for the HSP90 Chaperone Inhibitors Using AI-Augmented Integrative Biophysical Studies. Jacs Au, 4, 2024
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7XOE
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![BU of 7xoe by Molmil](/molmil-images/mine/7xoe) | Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Prefusion state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide | 著者 | Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J. | 登録日 | 2022-05-01 | 公開日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants. Sci Bull (Beijing), 68, 2023
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7XOG
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![BU of 7xog by Molmil](/molmil-images/mine/7xog) | Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Postfusion state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide, ... | 著者 | Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J. | 登録日 | 2022-05-01 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants. Sci Bull (Beijing), 68, 2023
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7KX5
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![BU of 7kx5 by Molmil](/molmil-images/mine/7kx5) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with noncovalent inhibitor Jun8-76-3A | 分子名称: | 3C-like proteinase, GLYCEROL, N-([1,1'-biphenyl]-4-yl)-N-[(1R)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]furan-2-carboxamide | 著者 | Sacco, M, Wang, J, Chen, Y. | 登録日 | 2020-12-03 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity. J.Am.Chem.Soc., 143, 2021
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7BRM
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![BU of 7brm by Molmil](/molmil-images/mine/7brm) | Architecture of curli complex | 分子名称: | Curli production assembly/transport protein CsgG, csgf | 著者 | Zhang, M, Shi, H. | 登録日 | 2020-03-29 | 公開日 | 2020-07-15 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structure of the nonameric CsgG-CsgF complex and its implications for controlling curli biogenesis in Enterobacteriaceae. Plos Biol., 18, 2020
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7N2O
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![BU of 7n2o by Molmil](/molmil-images/mine/7n2o) | AS4.2-YEIH-HLA*B27 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, GLYCEROL, ... | 著者 | Yang, X, Jude, K.M, Garcia, K.C. | 登録日 | 2021-05-29 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 612, 2022
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7N2Q
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![BU of 7n2q by Molmil](/molmil-images/mine/7n2q) | AS4.3-YEIH-HLA*B27 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, AS4.3 T cell receptor alpha chain, AS4.3 T cell receptor beta chain, ... | 著者 | Yang, X, Jude, K.M, Garcia, K.C. | 登録日 | 2021-05-29 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 612, 2022
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7N2S
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![BU of 7n2s by Molmil](/molmil-images/mine/7n2s) | AS3.1-PRPF3-HLA*B27 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, GLYCEROL, ... | 著者 | Yang, X, Jude, K.M, Garcia, K.C. | 登録日 | 2021-05-29 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 612, 2022
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7N2R
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![BU of 7n2r by Molmil](/molmil-images/mine/7n2r) | AS4.3-PRPF3-HLA*B27 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, AS4.3 T cell receptor alpha chain, ... | 著者 | Yang, X, Jude, K.M, Garcia, K.C. | 登録日 | 2021-05-29 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 612, 2022
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7N2N
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![BU of 7n2n by Molmil](/molmil-images/mine/7n2n) | TCR-antigen complex AS4.2-PRPF3-HLA*B27 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, GLYCEROL, ... | 著者 | Yang, X, Jude, K.M, Garcia, K.C. | 登録日 | 2021-05-29 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 612, 2022
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6G2X
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![BU of 6g2x by Molmil](/molmil-images/mine/6g2x) | Crystal structure of the p97 D2 domain in a helical split-washer conformation | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DIMETHYL SULFOXIDE, ... | 著者 | Stach, L, Morgan, R.M.L, Freemont, P.S. | 登録日 | 2018-03-23 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.078 Å) | 主引用文献 | Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding. Febs Lett., 594, 2020
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6G30
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![BU of 6g30 by Molmil](/molmil-images/mine/6g30) | Crystal structure of the p97 D2 domain in a helical split-washer conformation | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DIMETHYL SULFOXIDE, ... | 著者 | Stach, L, Morgan, R.M.L, Freemont, P.S. | 登録日 | 2018-03-23 | 公開日 | 2019-04-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.418 Å) | 主引用文献 | Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding. Febs Lett., 594, 2020
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7N2P
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![BU of 7n2p by Molmil](/molmil-images/mine/7n2p) | AS4.3-RNASEH2b-HLA*B27 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, AS4.3 T cell receptor alpha chain, AS4.3 T cell receptor beta chain, ... | 著者 | Yang, X, Jude, K.M, Garcia, K.C. | 登録日 | 2021-05-29 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 612, 2022
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6G2W
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![BU of 6g2w by Molmil](/molmil-images/mine/6g2w) | Crystal structure of the p97 D2 domain in a helical split-washer conformation | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DIMETHYL SULFOXIDE, ... | 著者 | Stach, L, Morgan, R.M.L, Freemont, P.S. | 登録日 | 2018-03-23 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.678 Å) | 主引用文献 | Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding. Febs Lett., 594, 2020
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6G2V
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![BU of 6g2v by Molmil](/molmil-images/mine/6g2v) | Crystal structure of the p97 D2 domain in a helical split-washer conformation | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DIMETHYL SULFOXIDE, ... | 著者 | Stach, L, Morgan, R.M.L, Freemont, P.S. | 登録日 | 2018-03-23 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.903 Å) | 主引用文献 | Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding. Febs Lett., 594, 2020
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3HIE
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![BU of 3hie by Molmil](/molmil-images/mine/3hie) | |
6G2Y
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![BU of 6g2y by Molmil](/molmil-images/mine/6g2y) | Crystal structure of the p97 D2 domain in a helical split-washer conformation | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DIMETHYL SULFOXIDE, ... | 著者 | Stach, L, Morgan, R.M.L, Freemont, P.S. | 登録日 | 2018-03-23 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.153 Å) | 主引用文献 | Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding. Febs Lett., 594, 2020
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6G2Z
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![BU of 6g2z by Molmil](/molmil-images/mine/6g2z) | Crystal structure of the p97 D2 domain in a helical split-washer conformation | 分子名称: | (3-phenyl-1,2-oxazol-5-yl)methylazanium, (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Stach, L, Morgan, R.M.L, Freemont, P.S. | 登録日 | 2018-03-23 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.923 Å) | 主引用文献 | Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding. Febs Lett., 594, 2020
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1O3S
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![BU of 1o3s by Molmil](/molmil-images/mine/1o3s) | PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES | 分子名称: | 5'-D(*AP*AP*AP*AP*AP*TP*GP*CP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*GP*CP*AP*TP*TP*TP*TP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | 著者 | Chen, S, Ebright, R.H, Berman, H.M. | 登録日 | 2003-03-18 | 公開日 | 2003-04-08 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: Alteration of DNA Binding Specificity Through Alteration of DNA Kinking J.Mol.Biol., 314, 2001
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1OO3
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![BU of 1oo3 by Molmil](/molmil-images/mine/1oo3) | |