6G2X

Crystal structure of the p97 D2 domain in a helical split-washer conformation

Summary for 6G2X

Entry DOI	10.2210/pdb6g2x/pdb
Descriptor	Transitional endoplasmic reticulum ATPase, (4S)-2-METHYL-2,4-PENTANEDIOL, DIMETHYL SULFOXIDE, ... (7 entities in total)
Functional Keywords	atpase, p97, protein degradation, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35749.68
Authors	Stach, L.,Morgan, R.M.L.,Freemont, P.S. (deposition date: 2018-03-23, release date: 2019-04-10, Last modification date: 2024-01-17)
Primary citation	Stach, L.,Morgan, R.M.,Makhlouf, L.,Douangamath, A.,von Delft, F.,Zhang, X.,Freemont, P.S. Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding. Febs Lett., 594:933-943, 2020 Cited by PubMed: 31701538 DOI: 10.1002/1873-3468.13667 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.078 Å)

Structure validation