8KI4

Crystal structure of human HSP90 in intermediate state

Summary for 8KI4

Entry DOI	10.2210/pdb8ki4/pdb
Descriptor	Heat shock protein HSP 90-alpha, 1,2-ETHANEDIOL (3 entities in total)
Functional Keywords	hsp90, atpase, ntd, chaperone
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	54799.25
Authors	Xu, C.,Zhang, X.L.,Bai, F. (deposition date: 2023-08-22, release date: 2024-04-17)
Primary citation	Xu, C.,Zhang, X.,Zhao, L.,Verkhivker, G.M.,Bai, F. Accurate Characterization of Binding Kinetics and Allosteric Mechanisms for the HSP90 Chaperone Inhibitors Using AI-Augmented Integrative Biophysical Studies Jacs Au, 2024 Cited by DOI: 10.1021/jacsau.4c00123 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation