8X03
 
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7YGI
 | | Crystal structure of p53 DBD domain in complex with azurin | | 分子名称: | Azurin, Cellular tumor antigen p53, PHOSPHATE ION, ... | | 著者 | Jiang, W.X, Zuo, J.Q, Hu, J.J, Chen, X.Q, Ma, L.X, Liu, Z, Xing, Q. | | 登録日 | 2022-07-11 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination.
Commun Biol, 6, 2023
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4FA8
 | | Multi-pronged modulation of cytokine signaling | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage colony-stimulating factor 1, Secreted protein BARF1, ... | | 著者 | He, X, Shim, A.H. | | 登録日 | 2012-05-21 | | 公開日 | 2012-08-29 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.
Proc.Natl.Acad.Sci.USA, 109, 2012
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6O1F
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7WKX
 | | IL-17A in complex with the humanized antibody HB0017 | | 分子名称: | ACETIC ACID, Heavy chain of HB0017 Fab, Interleukin-17A, ... | | 著者 | Xu, J, Zhu, X, He, Y. | | 登録日 | 2022-01-12 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Structural and functional insights into a novel pre-clinical-stage antibody targeting IL-17A for treatment of autoimmune diseases.
Int.J.Biol.Macromol., 202, 2022
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8JOT
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8JMZ
 | | FGFR1 kinase domain with sulfatinib | | 分子名称: | Fibroblast growth factor receptor 1, GLYCEROL, SULFATE ION, ... | | 著者 | Chen, X.J, Lin, Q.M, Chen, Y.H. | | 登録日 | 2023-06-05 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.988 Å) | | 主引用文献 | Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R.
Commun Chem, 7, 2024
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7WZ5
 | | Larimichthys crocea IFNi | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon C | | 著者 | Chen, J.J. | | 登録日 | 2022-02-17 | | 公開日 | 2023-02-08 | | 最終更新日 | 2025-04-02 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | Structural and Functional Characterization of a Fish Type I Subgroup d IFN Reveals Its Binding to Receptors.
J Immunol., 212, 2024
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7JM5
 | | Crystal structure of KDM4B in complex with QC6352 | | 分子名称: | 3-[({(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl}methyl)amino]pyridine-4-carboxylic acid, Lysine-specific demethylase 4B, NICKEL (II) ION, ... | | 著者 | White, S.W, Yun, M. | | 登録日 | 2020-07-31 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma.
Sci Transl Med, 14, 2022
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8WWF
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8WWE
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8WWD
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7VUE
 | | Structural insight of the molecular mechanism of cilofexor bound to FXR | | 分子名称: | 2-[3-[4-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-2-chloranyl-phenyl]-3-oxidanyl-azetidin-1-yl]pyridine-4-carboxylic acid, Bile acid receptor, Peptide from Nuclear receptor coactivator 2 | | 著者 | Jiang, L, Chen, Y.C. | | 登録日 | 2021-11-02 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | | 主引用文献 | Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor.
Biochem.Biophys.Res.Commun., 595, 2022
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6UG1
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5HP7
 | | Crystal structures of RidA in the apo form | | 分子名称: | Reactive Intermediate Deaminase A, chloroplastic | | 著者 | Xie, W, Liu, X. | | 登録日 | 2016-01-20 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structures of RidA, an important enzyme for the prevention of toxic side products
Sci Rep, 6, 2016
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5ZQZ
 | | Structure of human mitochondrial trifunctional protein, tetramer | | 分子名称: | Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta | | 著者 | Liang, K, Li, N, Dai, J, Wang, X, Liu, P, Chen, X, Wang, C, Gao, N, Xiao, J. | | 登録日 | 2018-04-20 | | 公開日 | 2018-06-20 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryo-EM structure of human mitochondrial trifunctional protein
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8WRH
 | | SARS-CoV-2 XBB.1.5.70 in complex with ACE2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S2' | | 著者 | Feng, L.L, Feng, L.L. | | 登録日 | 2023-10-14 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding.
Plos Pathog., 19, 2023
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8WRL
 | | XBB.1.5 RBD in complex with ACE2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike protein S1 | | 著者 | Feng, L.L, Feng, L.L. | | 登録日 | 2023-10-15 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding.
Plos Pathog., 19, 2023
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8WRM
 | | XBB.1.5 spike protein in complex with ACE2 | | 分子名称: | Processed angiotensin-converting enzyme 2, Spike glycoprotein | | 著者 | Feng, L.L, Feng, L.L. | | 登録日 | 2023-10-15 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (4.34 Å) | | 主引用文献 | Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding.
Plos Pathog., 19, 2023
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8WRO
 | | XBB.1.5.10 spike protein in complex with ACE2 | | 分子名称: | Processed angiotensin-converting enzyme 2, Spike glycoprotein,Spike glycoprotein,Spike glycoprotein,Fusion protein | | 著者 | Feng, L.L, Feng, L.L. | | 登録日 | 2023-10-15 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding.
Plos Pathog., 19, 2023
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8WTD
 | | XBB.1.5.10 RBD in complex with ACE2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S2' | | 著者 | Feng, L.L, Feng, L.L. | | 登録日 | 2023-10-18 | | 公開日 | 2023-12-13 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding.
Plos Pathog., 19, 2023
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8WTJ
 | | XBB.1.5.70 spike protein in complex with ACE2 | | 分子名称: | Processed angiotensin-converting enzyme 2, Spike glycoprotein | | 著者 | Feng, L.L, Feng, L.L. | | 登録日 | 2023-10-18 | | 公開日 | 2023-12-13 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (4.64 Å) | | 主引用文献 | Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding.
Plos Pathog., 19, 2023
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8WUY
 | | Crystal Structure of TR3 LBD in complex with para-positioned 3,4,5-trisubstituted benzene derivatives | | 分子名称: | Nuclear receptor subfamily 4immunitygroup A member 1, ~{N}-methyl-~{N}-octyl-3,4,5-tris(oxidanyl)benzamide | | 著者 | Hong, W.B, Chen, X.Q, Lin, T.W. | | 登録日 | 2023-10-21 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure-based design and synthesis of anti-fibrotic compounds derived from para-positioned 3,4,5-trisubstituted benzene.
Bioorg.Chem., 144, 2024
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5HP8
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6KHY
 | | The crystal structure of AsfvAP:AG | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (AGCGTCACCGACGAGGC), DNA(AGCGTCACCGACGAGG), ... | | 著者 | Chen, Y.Q, Gan, J.H. | | 登録日 | 2019-07-16 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.008 Å) | | 主引用文献 | A unique DNA-binding mode of African swine fever virus AP endonuclease.
Cell Discov, 6, 2020
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