8WUY

Crystal Structure of TR3 LBD in complex with para-positioned 3,4,5-trisubstituted benzene derivatives

Summary for 8WUY

Entry DOI	10.2210/pdb8wuy/pdb
Descriptor	Nuclear receptor subfamily 4immunitygroup A member 1, ~{N}-methyl-~{N}-octyl-3,4,5-tris(oxidanyl)benzamide (3 entities in total)
Functional Keywords	complex, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	55381.30
Authors	Hong, W.B.,Chen, X.Q.,Lin, T.W. (deposition date: 2023-10-21, release date: 2024-01-24, Last modification date: 2024-01-31)
Primary citation	Hong, W.,Xiao, T.,Lin, G.,Liu, C.,Li, H.,Li, Y.,Hu, H.,Wu, S.,Wang, S.,Liang, Z.,Lin, T.,Liu, J.,Chen, X. Structure-based design and synthesis of anti-fibrotic compounds derived from para-positioned 3,4,5-trisubstituted benzene. Bioorg.Chem., 144:107113-107113, 2024 Cited by PubMed: 38232685 DOI: 10.1016/j.bioorg.2024.107113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation