7ACF
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5BPE
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5B5R
| Crystal structure of GSDMA3 | 分子名称: | Gasdermin-A3 | 著者 | Ding, J, Shao, F. | 登録日 | 2016-05-14 | 公開日 | 2016-06-15 | 最終更新日 | 2017-09-27 | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | 主引用文献 | Pore-forming activity and structural autoinhibition of the gasdermin family. Nature, 535, 2016
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4M0U
| crystal structure of human PRS1 Q133P mutant | 分子名称: | Ribose-phosphate pyrophosphokinase 1, SULFATE ION | 著者 | Chen, P, Teng, M, Li, X. | 登録日 | 2013-08-02 | 公開日 | 2015-02-04 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations Plos One, 10, 2015
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8YKY
| Structure of human class T GPCR TAS2R14-Ggustducin complex with agonist 28.1 | 分子名称: | 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, G alpha gustducin protein, ... | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | 登録日 | 2024-03-05 | 公開日 | 2024-07-10 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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5GUF
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6GJ5
| CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH 15 | 分子名称: | (3~{S})-3-[2-[(2~{R})-pyrrolidin-2-yl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ... | 著者 | Kessler, D, Mcconnell, D.M, Mantoulidis, A. | 登録日 | 2018-05-16 | 公開日 | 2019-07-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | 主引用文献 | Drugging an undruggable pocket on KRAS. Proc.Natl.Acad.Sci.USA, 116, 2019
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6GJ7
| CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH 22 | 分子名称: | (3~{S})-5-oxidanyl-3-[2-[[[1-(phenylmethyl)indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ... | 著者 | Kessler, D, Mcconnell, D.M, Mantoulidis, A. | 登録日 | 2018-05-16 | 公開日 | 2019-07-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Drugging an undruggable pocket on KRAS. Proc.Natl.Acad.Sci.USA, 116, 2019
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6GJ6
| CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH 18 | 分子名称: | (3~{S})-3-[2-[(dimethylamino)methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ... | 著者 | Kessler, D, Mcconnell, D.M, Mantoulidis, A, Phan, J. | 登録日 | 2018-05-16 | 公開日 | 2019-07-31 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.761 Å) | 主引用文献 | Drugging an undruggable pocket on KRAS. Proc.Natl.Acad.Sci.USA, 116, 2019
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6GJ8
| CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH BI 2852 | 分子名称: | (3~{S})-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ... | 著者 | Kessler, D, Mcconnell, D.M, Mantoulidis, A. | 登録日 | 2018-05-16 | 公開日 | 2019-07-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Drugging an undruggable pocket on KRAS. Proc.Natl.Acad.Sci.USA, 116, 2019
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5JLJ
| Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1 | 分子名称: | (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, CHLORIDE ION, Exportin-1, ... | 著者 | Fung, H.Y, Chook, Y.M. | 登録日 | 2016-04-27 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia, 30, 2016
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7L5E
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7BZF
| COVID-19 RNA-dependent RNA polymerase post-translocated catalytic complex | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA (31-MER), ... | 著者 | Wang, Q, Gao, Y, Ji, W, Mu, A, Rao, Z. | 登録日 | 2020-04-27 | 公開日 | 2020-06-03 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase. Cell, 182, 2020
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3M0K
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7BTF
| SARS-CoV-2 RNA-dependent RNA polymerase in complex with cofactors in reduced condition | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ... | 著者 | Gao, Y, Yan, L, Huang, Y, Liu, F, Cao, L, Wang, T, Wang, Q, Lou, Z, Rao, Z. | 登録日 | 2020-04-01 | 公開日 | 2020-04-08 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science, 368, 2020
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3M0J
| Structure of oxaloacetate acetylhydrolase in complex with the inhibitor 3,3-difluorooxalacetate | 分子名称: | 2,2-difluoro-3,3-dihydroxybutanedioic acid, CALCIUM ION, MANGANESE (II) ION, ... | 著者 | Herzberg, O, Chen, C. | 登録日 | 2010-03-03 | 公開日 | 2010-06-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure of oxalacetate acetylhydrolase, a virulence factor of the chestnut blight fungus. J.Biol.Chem., 285, 2010
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3LYE
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5T8G
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8UH6
| Degrader-induced complex between PTPN2 and CRBN-DDB1 | 分子名称: | (5P)-3-(carboxymethoxy)-4-chloro-5-(3-{[(4S)-1-({3-[(4-{1-[(3R)-2,6-dioxopiperidin-3-yl]-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl}piperidine-1-carbonyl)amino]phenyl}methanesulfonyl)-2,2-dimethylpiperidin-4-yl]amino}phenyl)thiophene-2-carboxylic acid, DNA damage-binding protein 1, Protein cereblon, ... | 著者 | Catalano, C, Bratkowski, M, Scapin, G, Hao, Q. | 登録日 | 2023-10-06 | 公開日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex. Commun Chem, 7, 2024
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8U0H
| Crystal structure of PTPN2 with a PROTAC | 分子名称: | (5P)-3-(carboxymethoxy)-4-chloro-5-(3-{[(4S)-1-({3-[2-(4-{3-[(3R)-2,6-dioxopiperidin-3-yl]-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl}piperidin-1-yl)acetamido]phenyl}methanesulfonyl)-2,2-dimethylpiperidin-4-yl]amino}phenyl)thiophene-2-carboxylic acid, ACETATE ION, PTPN2, ... | 著者 | Jain, R, Longenecker, K, Qiu, W. | 登録日 | 2023-08-29 | 公開日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex. Commun Chem, 7, 2024
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8XQP
| Structure of human class T GPCR TAS2R14-Gustducin complex with Aristolochic acid A. | 分子名称: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | 登録日 | 2024-01-05 | 公開日 | 2024-07-10 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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8XQN
| Structure of human class T GPCR TAS2R14-DNGi complex with Aristolochic acid A. | 分子名称: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | 登録日 | 2024-01-05 | 公開日 | 2024-07-10 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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8XQL
| Structure of human class T GPCR TAS2R14-miniGs/gust complex with Aristolochic acid A. | 分子名称: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | 登録日 | 2024-01-05 | 公開日 | 2024-07-10 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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8XQT
| Structure of human class T GPCR TAS2R14-Gi complex. | 分子名称: | CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hu, X.L, Pei, Y, Wu, L.J, Hua, T, Liu, Z.J. | 登録日 | 2024-01-05 | 公開日 | 2024-07-10 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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8XQR
| Structure 2 of human class T GPCR TAS2R14-miniGs/gust complex with Flufenamic acid. | 分子名称: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | 登録日 | 2024-01-05 | 公開日 | 2024-07-10 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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