6GJ7

CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH 22

Summary for 6GJ7

• Entry DOI: 10.2210/pdb6gj7/pdb
• Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... (5 entities in total)
• Functional Keywords: kras 4b, k-ras 2, ki-ras, c-k-ras, c-ki-ras, gtpase kras, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 20444.96

Authors

Kessler, D.,Mcconnell, D.M.,Mantoulidis, A. (deposition date: 2018-05-16, release date: 2019-07-31, Last modification date: 2024-01-17)

• Primary citation: Kessler, D.,Gmachl, M.,Mantoulidis, A.,Martin, L.J.,Zoephel, A.,Mayer, M.,Gollner, A.,Covini, D.,Fischer, S.,Gerstberger, T.,Gmaschitz, T.,Goodwin, C.,Greb, P.,Haring, D.,Hela, W.,Hoffmann, J.,Karolyi-Oezguer, J.,Knesl, P.,Kornigg, S.,Koegl, M.,Kousek, R.,Lamarre, L.,Moser, F.,Munico-Martinez, S.,Peinsipp, C.,Phan, J.,Rinnenthal, J.,Sai, J.,Salamon, C.,Scherbantin, Y.,Schipany, K.,Schnitzer, R.,Schrenk, A.,Sharps, B.,Siszler, G.,Sun, Q.,Waterson, A.,Wolkerstorfer, B.,Zeeb, M.,Pearson, M.,Fesik, S.W.,McConnell, D.B.; Drugging an undruggable pocket on KRAS.; Proc.Natl.Acad.Sci.USA, 116:15823-15829, 2019; PubMed: 31332011; DOI: 10.1073/pnas.1904529116

Experimental method

X-RAY DIFFRACTION (1.67 Å)