5TF9
 
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5EHR
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5EHP
 | | Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP836 | | 分子名称: | 5-[2,3-bis(chloranyl)phenyl]-2-[(3~{R},5~{S})-3,5-dimethylpiperazin-1-yl]pyrimidin-4-amine, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 | | 著者 | Stams, T, Fodor, M. | | 登録日 | 2015-10-28 | | 公開日 | 2016-07-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
J.Med.Chem., 59, 2016
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4FWE
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5B6E
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4FWF
 | | Complex structure of LSD2/AOF1/KDM1b with H3K4 mimic | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.1, Lysine-specific histone demethylase 1B, ... | | 著者 | Zhang, Q, Chen, Z. | | 登録日 | 2012-07-01 | | 公開日 | 2013-01-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b
Cell Res., 23, 2013
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5B6D
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4FWJ
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6SIY
 | | PaaK family AMP-ligase with AMP and substrate | | 分子名称: | 1,2-ETHANEDIOL, 3-HYDROXYANTHRANILIC ACID, ADENOSINE MONOPHOSPHATE, ... | | 著者 | Naismith, J.H, Song, H. | | 登録日 | 2019-08-12 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The Biosynthesis of the Benzoxazole in Nataxazole Proceeds via an Unstable Ester and has Synthetic Utility.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6SJ0
 | | Amidohydrolase, AHS | | 分子名称: | Amidohydrolase, BICARBONATE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Naismith, J.H, Song, H. | | 登録日 | 2019-08-12 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | The Biosynthesis of the Benzoxazole in Nataxazole Proceeds via an Unstable Ester and has Synthetic Utility.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6SIX
 | | PaaK family AMP-ligase with ANP | | 分子名称: | 1,2-ETHANEDIOL, AMP-dependent synthetase and ligase, CITRATE ANION, ... | | 著者 | Naismith, J.H, Song, H. | | 登録日 | 2019-08-12 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | The Biosynthesis of the Benzoxazole in Nataxazole Proceeds via an Unstable Ester and has Synthetic Utility.
Angew.Chem.Int.Ed.Engl., 59, 2020
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8JWN
 | | Crystal structure of AKRtyl-NADPH complex | | 分子名称: | Aldo/keto reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Lin, S, Dai, S, Xiao, Z. | | 登録日 | 2023-06-29 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.
Nat Commun, 15, 2024
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8JWO
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8JWL
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8JWK
 | | The second purified state crystal structure of AKRtyl | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Aldo/keto reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Lin, S, Dai, S, Xiao, Z. | | 登録日 | 2023-06-29 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.
Nat Commun, 15, 2024
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8JWM
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6TM4
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5JNH
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8K4Q
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8GRQ
 | | Cryo-EM structure of BRCA1/BARD1 bound to H2AK127-UbcH5c-Ub nucleosome | | 分子名称: | BRCA1-associated RING domain protein 1, Breast cancer type 1 susceptibility protein, DNA (147-MER), ... | | 著者 | Ai, H.S, Zebin, T, Zhiheng, D, Jiakun, T, Liying, Z, Jia-Bin, L, Man, P, Liu, L. | | 登録日 | 2022-09-02 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | | 主引用文献 | Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination.
Chem, 2023
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8GRM
 | | Cryo-EM structure of PRC1 bound to H2AK119-UbcH5b-Ub nucleosome | | 分子名称: | COMMD3 protein, DNA (144-MER), DNA (145-MER), ... | | 著者 | Ai, H.S, Zebin, T, Zhihend, D, Jiakun, T, Liying, Z, Jia-Bin, L, Man, P, Liu, L. | | 登録日 | 2022-09-02 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination.
Chem, 2023
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8I4Z
 | | CalA3 with hydrolysis product | | 分子名称: | 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, Beta-ketoacyl-acyl-carrier-protein synthase I | | 著者 | Wang, J, Wang, Z. | | 登録日 | 2023-01-21 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | | 主引用文献 | C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
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8I4Y
 | | CalA3 complex structure with amidation product | | 分子名称: | 11-oxidanylidene-11-(1~{H}-pyrrol-2-yl)undecanoic acid, 3-HYDROXYANTHRANILIC ACID, Beta-ketoacyl-acyl-carrier-protein synthase I | | 著者 | Wang, J, Wang, Z. | | 登録日 | 2023-01-21 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | | 主引用文献 | C-N bond formation by a polyketide synthase.
Nat Commun, 14, 2023
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7FH5
 | | Structure of AdaV | | 分子名称: | AdaV, CHLORIDE ION, FE (III) ION | | 著者 | Zhang, Z.Y, Chen, W.Q, Zhai, G.Q, Zhang, M. | | 登録日 | 2021-07-29 | | 公開日 | 2022-08-03 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis
Acs Catalysis, 12, 2022
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8HR1
 | | Cryo-EM structure of SSX1 bound to the unmodified nucleosome at a resolution of 3.02 angstrom | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Zebin, T, Ai, H.S, Ziyu, X, Man, P, Liu, L. | | 登録日 | 2022-12-14 | | 公開日 | 2023-09-13 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes.
Nat.Struct.Mol.Biol., 31, 2024
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