8K4Q
Crystal structure of nanobody HuNb103 bound to human interleukin-4 receptor subunit alpha
Summary for 8K4Q
Entry DOI | 10.2210/pdb8k4q/pdb |
Descriptor | Interleukin-4 receptor subunit alpha, IL-4R nanobody HuNb103, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | antibody, complex, il-4r, il-4, il-13, cytokine |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 78232.73 |
Authors | Ding, Y.,Zhong, P.Y. (deposition date: 2023-07-20, release date: 2024-06-26, Last modification date: 2024-07-03) |
Primary citation | Zhu, M.,Ma, L.,Zhong, P.,Huang, J.,Gai, J.,Li, G.,Li, Y.,Qiao, P.,Gu, H.,Li, X.,Yin, Y.,Zhang, L.,Deng, Z.,Sun, B.,Chen, Z.,Ding, Y.,Wan, Y. A Novel Inhalable Nanobody Targeting IL-4R alpha for the Treatment of Asthma. J.Allergy Clin.Immunol., 2024 Cited by PubMed: 38871183DOI: 10.1016/j.jaci.2024.05.027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.59 Å) |
Structure validation
Download full validation report