8K4Q

Crystal structure of nanobody HuNb103 bound to human interleukin-4 receptor subunit alpha

Summary for 8K4Q

Entry DOI	10.2210/pdb8k4q/pdb
Descriptor	Interleukin-4 receptor subunit alpha, IL-4R nanobody HuNb103, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	antibody, complex, il-4r, il-4, il-13, cytokine
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	78232.73
Authors	Ding, Y.,Zhong, P.Y. (deposition date: 2023-07-20, release date: 2024-06-26, Last modification date: 2024-10-23)
Primary citation	Zhu, M.,Ma, L.,Zhong, P.,Huang, J.,Gai, J.,Li, G.,Li, Y.,Qiao, P.,Gu, H.,Li, X.,Yin, Y.,Zhang, L.,Deng, Z.,Sun, B.,Chen, Z.,Ding, Y.,Wan, Y. A novel inhalable nanobody targeting IL-4R alpha for the treatment of asthma. J.Allergy Clin.Immunol., 154:1008-1021, 2024 Cited by PubMed Abstract: Inhalable biologics represent a promising approach to improve the efficacy and safety of asthma treatment. Although several monoclonal antibodies (mAbs) targeting IL-4Rα have been approved or are undergoing clinical trials, the development of inhalable mAbs targeting IL-4Rα presents significant challenges. PubMed: 38871183 DOI: 10.1016/j.jaci.2024.05.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.59 Å)

Structure validation