8K4Q
Crystal structure of nanobody HuNb103 bound to human interleukin-4 receptor subunit alpha
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Interleukin-4 receptor subunit alpha | polymer | 214 | 24606.6 | 2 | UniProt (Q53EP8) Pfam (PF09238) UniProt (by SIFTS) (P24394) | Homo sapiens (human) | |
| 2 | B, D (B, D) | IL-4R nanobody HuNb103 | polymer | 121 | 13056.5 | 2 | Camelus dromedarius | ||
| 3 | E, G (E, G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 4 | F, H (F, H) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 5 | I, J, K, L (A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 6 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 207 (UniProt: Q53EP8)
| PDB | External Database | Details |
|---|---|---|
| Glu 208 | - | expression tag |
| Asn 209 | - | expression tag |
| Leu 210 | - | expression tag |
| Tyr 211 | - | expression tag |
| Phe 212 | - | expression tag |
| Gln 213 | - | expression tag |
| Gly 214 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 75326.0 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2021.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 884.8 | |
| All* | Total formula weight | 78232.7 |
