4KC3
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![BU of 4kc3 by Molmil](/molmil-images/mine/4kc3) | Cytokine/receptor binary complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 receptor-like 1, Interleukin-33 | 著者 | Liu, X, Wang, X.Q. | 登録日 | 2013-04-24 | 公開日 | 2013-08-28 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (3.2702 Å) | 主引用文献 | Structural insights into the interaction of IL-33 with its receptors. Proc.Natl.Acad.Sci.USA, 110, 2013
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3SIE
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![BU of 3sie by Molmil](/molmil-images/mine/3sie) | |
4I5S
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![BU of 4i5s by Molmil](/molmil-images/mine/4i5s) | Structure and function of sensor histidine kinase | 分子名称: | Putative histidine kinase CovS; VicK-like protein | 著者 | Cai, Y. | 登録日 | 2012-11-28 | 公開日 | 2013-03-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains Plos Biol., 11, 2013
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2HH4
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![BU of 2hh4 by Molmil](/molmil-images/mine/2hh4) | NMR structure of human insulin mutant GLY-B8-D-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures | 分子名称: | insulin A chain, insulin B chain | 著者 | Hua, Q.X, Nakagawa, S, Hu, S.Q, Jia, W, Weiss, M.A. | 登録日 | 2006-06-27 | 公開日 | 2006-07-18 | 最終更新日 | 2021-10-20 | 実験手法 | SOLUTION NMR | 主引用文献 | Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain. J.Biol.Chem., 281, 2006
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2HHO
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![BU of 2hho by Molmil](/molmil-images/mine/2hho) | NMR structure of human insulin mutant GLY-B8-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures | 分子名称: | Insulin A chain, Insulin B chain | 著者 | Hua, Q.X, Nakagawa, S, Hu, S.Q, Jia, W, Weiss, M.A. | 登録日 | 2006-06-28 | 公開日 | 2006-07-18 | 最終更新日 | 2021-10-20 | 実験手法 | SOLUTION NMR | 主引用文献 | Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain. J.Biol.Chem., 281, 2006
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8ILE
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![BU of 8ile by Molmil](/molmil-images/mine/8ile) | The crystal structure of dGTPalphaSe-Rp:DNApre-II:Pol X substrate ternary complex | 分子名称: | DNA (5'-D(*CP*TP*GP*GP*AP*TP*CP*CP*A)-3'), MANGANESE (II) ION, Repair DNA polymerase X, ... | 著者 | Qin, T, Gan, J.H, Huang, Z. | 登録日 | 2023-03-03 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom. Int J Mol Sci, 24, 2023
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8ILG
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![BU of 8ilg by Molmil](/molmil-images/mine/8ilg) | The crystal structure of dG-DNA:Pol X product binary complex | 分子名称: | DNA (5'-D(*CP*GP*GP*AP*TP*CP*CP*G)-3'), FORMIC ACID, MANGANESE (II) ION, ... | 著者 | Qin, T, Gan, J.H, Huang, Z. | 登録日 | 2023-03-03 | 公開日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.805 Å) | 主引用文献 | Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom. Int J Mol Sci, 24, 2023
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6MDZ
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2JK7
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![BU of 2jk7 by Molmil](/molmil-images/mine/2jk7) | XIAP BIR3 bound to a Smac Mimetic | 分子名称: | (3S,6S,7Z,10AS)-N-(DIPHENYLMETHYL)-6-{[(2S)-2-(METHYLIDENEAMINO)BUTANOYL]AMINO}-5-OXO-1,2,3,5,6,9,10,10A-OCTAHYDROPYRROLO[1,2-A]AZOCINE-3-CARBOXAMIDE, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, ZINC ION | 著者 | Saito, N.G, Meagher, J.L, Stuckey, J.A. | 登録日 | 2008-08-21 | 公開日 | 2008-11-04 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (Xiap). J.Med.Chem., 51, 2008
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8ILF
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![BU of 8ilf by Molmil](/molmil-images/mine/8ilf) | The crystal structure of dGTPalphaSe-Sp:DNApre-II:Pol X substrate ternary complex | 分子名称: | DNA (5'-D(*CP*TP*GP*GP*AP*TP*CP*CP*A)-3'), MANGANESE (II) ION, Repair DNA polymerase X, ... | 著者 | Qin, T, Zhao, Q.W, Gan, J.H, Huang, Z. | 登録日 | 2023-03-03 | 公開日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom. Int J Mol Sci, 24, 2023
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7E57
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![BU of 7e57 by Molmil](/molmil-images/mine/7e57) | Crystal structure of murine GITR-GITRL complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor receptor superfamily member 18, ... | 著者 | Zhao, M, Tan, S, Fu, L, Chai, Y, Qi, J, Gao, G.F. | 登録日 | 2021-02-18 | 公開日 | 2021-09-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.302 Å) | 主引用文献 | Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation. Cell Rep, 36, 2021
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6MFR
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6MFN
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8CZH
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![BU of 8czh by Molmil](/molmil-images/mine/8czh) | Human BAK in complex with the dM2 peptide | 分子名称: | Bcl-2 homologous antagonist/killer, DM2 peptide | 著者 | Aguilar, F, Keating, A.E. | 登録日 | 2022-05-24 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization. Structure, 31, 2023
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8CZF
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![BU of 8czf by Molmil](/molmil-images/mine/8czf) | Human BAK in complex with the dF2 peptide | 分子名称: | Bcl-2 homologous antagonist/killer, DF2 peptide | 著者 | Aguilar, F, Keating, A.E. | 登録日 | 2022-05-24 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization. Structure, 31, 2023
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8CZG
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![BU of 8czg by Molmil](/molmil-images/mine/8czg) | Human BAK in complex with the dF3 peptide | 分子名称: | Bcl-2 homologous antagonist/killer, dF3 peptide | 著者 | Aguilar, F, Keating, A.E. | 登録日 | 2022-05-24 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization. Structure, 31, 2023
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6NIT
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8DVN
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![BU of 8dvn by Molmil](/molmil-images/mine/8dvn) | Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.10 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Thakur, A.K, Liau, N.P.D, Sudhamsu, J, Hannoush, R.N. | 登録日 | 2022-07-29 | 公開日 | 2023-03-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering. Acs Chem.Biol., 18, 2023
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8DVL
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![BU of 8dvl by Molmil](/molmil-images/mine/8dvl) | Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.18 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Thakur, A.K, Liau, N.P.D, Sudhamsu, J, Hannoush, R.N. | 登録日 | 2022-07-29 | 公開日 | 2023-03-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering. Acs Chem.Biol., 18, 2023
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8DVM
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![BU of 8dvm by Molmil](/molmil-images/mine/8dvm) | Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.6 | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Thakur, A.K, Liau, N.P.D, Sudhamsu, J, Hannoush, R.N. | 登録日 | 2022-07-29 | 公開日 | 2023-03-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering. Acs Chem.Biol., 18, 2023
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2XAB
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![BU of 2xab by Molmil](/molmil-images/mine/2xab) | Structure of HSP90 with an inhibitor bound | 分子名称: | 4-(1,3-DIHYDRO-2H-ISOINDOL-2-YLCARBONYL)-6-(1-METHYLETHYL)BENZENE-1,3-DIOL, HEAT SHOCK PROTEIN HSP 90-ALPHA, | 著者 | Murray, C.W, Carr, M.G, Callaghan, O, Chessari, G, Congreve, m, Cowan, S, Coyle, J.E, Downham, R, Figueroa, E, Frederickson, M, Graham, B, McMenamin, R, O'Brian, M.A, Patel, S, Phillips, T.R, Williams, G, Woodhead, A.J, Woolford, A.J.A. | 登録日 | 2010-03-30 | 公開日 | 2010-08-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of (2,4-Dihydroxy-5-Isopropylphenyl)-[5-(4-Methylpiperazin-1-Ylmethyl)-1,3-Dihydroisoindol-2-Yl]Methanone (at13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design. J.Med.Chem., 53, 2010
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6VKL
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2XJJ
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![BU of 2xjj by Molmil](/molmil-images/mine/2xjj) | Structure of HSP90 with small molecule inhibitor bound | 分子名称: | 1,3-DIHYDROISOINDOL-2-YL-(6-HYDROXY-3,3-DIMETHYL-1,2-DIHYDROINDOL-5-YL)METHANONE, GLYCEROL, HEAT SHOCK PROTEIN HSP 90-ALPHA | 著者 | Murray, C.W, Carr, M.G, Callaghan, O, Chessari, G, Congreve, M, Cowan, S, Coyle, J.E, Downham, R, Figueroa, E, Frederickson, M, Graham, B, McMenamin, R, OBrien, M.A, Patel, S, Phillips, T.R, Williams, G, Woodhead, A.J, Woolford, A.J.A. | 登録日 | 2010-07-06 | 公開日 | 2010-08-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of (2,4-Dihydroxy-5-Isopropylphenyl)-[5-(4-Methylpiperazin-1-Ylmethyl)-1,3-Dihydroisoindol-2-Yl]Methanone (at13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design. J.Med.Chem., 53, 2010
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3QQU
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![BU of 3qqu by Molmil](/molmil-images/mine/3qqu) | Cocrystal structure of unphosphorylated igf with pyrimidine 8 | 分子名称: | Insulin-like growth factor 1 receptor, N~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-N~4~-(quinolin-3-yl)pyrimidine-2,4-diamine | 著者 | Huang, X. | 登録日 | 2011-02-16 | 公開日 | 2011-04-20 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
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4RIK
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![BU of 4rik by Molmil](/molmil-images/mine/4rik) | Amyloid forming segment, AVVTGVTAV, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 69-77 | 分子名称: | Alpha-synuclein | 著者 | Guenther, E.L, Sawaya, M.R, Ivanova, M, Eisenberg, D.S. | 登録日 | 2014-10-06 | 公開日 | 2015-08-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.854 Å) | 主引用文献 | Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525, 2015
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