6MFR

Human Argonaute2-miR-122 bound to a target RNA with three central mismatches (bu3)

Summary for 6MFR

• Entry DOI: 10.2210/pdb6mfr/pdb
• Descriptor: Protein argonaute-2, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*U)-3'), RNA (5'-R(P*AP*AP*AP*CP*AP*CP*CP*AP*UP*UP*UP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), ... (5 entities in total)
• Functional Keywords: rna-binding protein, microrna, target directed microrna decay, hydrolase, hydrolase-rna complex, hydrolase/rna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 223248.68

Authors

Sheu-Gruttadauria, J.,MacRae, I.J. (deposition date: 2018-09-12, release date: 2019-08-07, Last modification date: 2023-10-11)

• Primary citation: Sheu-Gruttadauria, J.,Pawlica, P.,Klum, S.M.,Wang, S.,Yario, T.A.,Schirle Oakdale, N.T.,Steitz, J.A.,MacRae, I.J.; Structural Basis for Target-Directed MicroRNA Degradation.; Mol.Cell, 75:1243-1255.e7, 2019; PubMed: 31353209; DOI: 10.1016/j.molcel.2019.06.019

Experimental method

X-RAY DIFFRACTION (3.6 Å)