2JK7

XIAP BIR3 bound to a Smac Mimetic

Summary for 2JK7

• Entry DOI: 10.2210/pdb2jk7/pdb
• Related: 1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2VSL
• Descriptor: BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, (3S,6S,7Z,10AS)-N-(DIPHENYLMETHYL)-6-{[(2S)-2-(METHYLIDENEAMINO)BUTANOYL]AMINO}-5-OXO-1,2,3,5,6,9,10,10A-OCTAHYDROPYRROLO[1,2-A]AZOCINE-3-CARBOXAMIDE, ZINC ION, ... (4 entities in total)
• Functional Keywords: zinc-finger, polymorphism, smac mimetic, metal-binding, bir3, zinc, ligase, apoptosis, cytoplasm, x-linked inhibitor of apoptosis, ubl conjugation pathway, thiol protease inhibitor, phosphoprotein, ubl conjugation, protease inhibitor
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: P98170
• Total number of polymer chains: 1
• Total formula weight: 13845.77

Authors

Saito, N.G.,Meagher, J.L.,Stuckey, J.A. (deposition date: 2008-08-21, release date: 2008-11-04, Last modification date: 2011-07-13)

• Primary citation: Sun, H.,Stuckey, J.A.,Nikolovska-Coleska, Z.,Qin, D.,Meagher, J.L.,Qiu, S.,Lu, J.,Yang, C.,Saito, N.G.,Wang, S.; Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (Xiap).; J.Med.Chem., 51:7169-, 2008; PubMed: 18954041; DOI: 10.1021/JM8006849

Experimental method

X-RAY DIFFRACTION (2.82 Å)