6MFN

Human Argonaute2-miR-27a bound to HSUR1 target RNA

Summary for 6MFN

• Entry DOI: 10.2210/pdb6mfn/pdb
• Descriptor: Protein argonaute-2, RNA (5'-R(P*UP*UP*CP*AP*CP*AP*GP*UP*G)-3'), RNA (5'-R(P*UP*CP*UP*GP*UP*GP*AP*UP*AP*A)-3'), ... (5 entities in total)
• Functional Keywords: rna-binding protein, microrna, target directed microrna decay, hydrolase-rna complex, hydrolase/rna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 111146.50

Authors

Sheu-Gruttadauria, J.,MacRae, I.J. (deposition date: 2018-09-11, release date: 2019-08-07, Last modification date: 2023-10-11)

• Primary citation: Sheu-Gruttadauria, J.,Pawlica, P.,Klum, S.M.,Wang, S.,Yario, T.A.,Schirle Oakdale, N.T.,Steitz, J.A.,MacRae, I.J.; Structural Basis for Target-Directed MicroRNA Degradation.; Mol.Cell, 75:1243-, 2019; PubMed: 31353209; DOI: 10.1016/j.molcel.2019.06.019

Experimental method

X-RAY DIFFRACTION (2.5 Å)