6MFN
Human Argonaute2-miR-27a bound to HSUR1 target RNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein argonaute-2 | polymer | 859 | 97358.2 | 1 | UniProt (Q9UKV8) Pfam (PF16486) Pfam (PF08699) Pfam (PF02170) Pfam (PF16488) Pfam (PF16487) Pfam (PF02171) In PDB | Homo sapiens (Human) | hAgo2, Argonaute RISC catalytic component 2, Eukaryotic translation initiation factor 2C 2, eIF2C 2, PAZ Piwi domain protein, PPD, Protein slicer |
| 2 | C | RNA (5'-R(P*UP*UP*CP*AP*CP*AP*GP*UP*G)-3') | polymer | 21 | 6666.0 | 1 | Homo sapiens | ||
| 3 | E | RNA (5'-R(P*UP*CP*UP*GP*UP*GP*AP*UP*AP*A)-3') | polymer | 22 | 7028.2 | 1 | synthetic construct | ||
| 4 | A | PHENOL | non-polymer | 94.1 | 1 | Chemie (IPH) | |||
| 5 | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A: 1 - 859 (UniProt: Q9UKV8)
| PDB | External Database | Details |
|---|---|---|
| Asp 387 | Ser 387 | engineered mutation |
| Ala 669 | Asp 669 | engineered mutation |
| Ala 824 | Ser 824 | engineered mutation |
| Asp 828 | Ser 828 | engineered mutation |
| Asp 831 | Ser 831 | engineered mutation |
| Ala 834 | Ser 834 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 111052.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 94.1 | |
| All* | Total formula weight | 111146.5 |
