2P6B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2p6b by Molmil](/molmil-images/mine/2p6b) | Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide | 分子名称: | CALCIUM ION, Calcineurin subunit B isoform 1, Calmodulin-dependent calcineurin A subunit alpha isoform, ... | 著者 | Li, H, Zhang, L, Rao, A, Harrison, S.C, Hogan, P.G. | 登録日 | 2007-03-16 | 公開日 | 2007-06-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction J.Mol.Biol., 369, 2007
|
|
7VNI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vni by Molmil](/molmil-images/mine/7vni) | AHR-ARNT PAS-B heterodimer | 分子名称: | Ahr homolog spineless, Aryl hydrocarbon receptor nuclear translocator, SULFATE ION | 著者 | Dai, S.Y. | 登録日 | 2021-10-11 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
|
|
7VNA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vna by Molmil](/molmil-images/mine/7vna) | drosophlia AHR PAS-B domain | 分子名称: | Ahr homolog spineless | 著者 | Dai, S.Y. | 登録日 | 2021-10-10 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.597 Å) | 主引用文献 | Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun, 13, 2022
|
|
7VNH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vnh by Molmil](/molmil-images/mine/7vnh) | |
7WCT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wct by Molmil](/molmil-images/mine/7wct) | Crystal structure of FGFR4 kinase domain with 7v | 分子名称: | Fibroblast growth factor receptor 4, GLYCEROL, SULFATE ION, ... | 著者 | Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H. | 登録日 | 2021-12-20 | 公開日 | 2022-03-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.106 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4. J.Med.Chem., 65, 2022
|
|
7WCW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wcw by Molmil](/molmil-images/mine/7wcw) | Crystal structure of FGFR4(V550L) kinase domain with 7v | 分子名称: | Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide | 著者 | Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H. | 登録日 | 2021-12-20 | 公開日 | 2022-03-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.317 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4. J.Med.Chem., 65, 2022
|
|
7WCX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wcx by Molmil](/molmil-images/mine/7wcx) | Crystal structure of FGFR4(V550M) kinase domain with 7v | 分子名称: | Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide | 著者 | Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H. | 登録日 | 2021-12-20 | 公開日 | 2022-03-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.175 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4. J.Med.Chem., 65, 2022
|
|
7YBO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ybo by Molmil](/molmil-images/mine/7ybo) | Crystal structure of FGFR4 kinase domain with 10z | 分子名称: | Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide | 著者 | Chen, X.J, Lin, Q.M, Chen, Y.H. | 登録日 | 2022-06-29 | 公開日 | 2022-11-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.307 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. J.Med.Chem., 65, 2022
|
|
7YC3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yc3 by Molmil](/molmil-images/mine/7yc3) | Crystal structure of FGFR4 kinase domain with 10t | 分子名称: | 6-bromanyl-~{N}-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide, Fibroblast growth factor receptor 4, GLYCEROL, ... | 著者 | Chen, X.J, Lin, Q.M, Chen, Y.H. | 登録日 | 2022-06-30 | 公開日 | 2022-11-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.987 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. J.Med.Chem., 65, 2022
|
|
7YC1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yc1 by Molmil](/molmil-images/mine/7yc1) | Crystal structure of FGFR4 kinase domain with 10d | 分子名称: | Fibroblast growth factor receptor 4, GLYCEROL, SULFATE ION, ... | 著者 | Chen, X.J, Lin, Q.M, Chen, Y.H. | 登録日 | 2022-06-30 | 公開日 | 2022-11-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.535 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. J.Med.Chem., 65, 2022
|
|
7YBP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ybp by Molmil](/molmil-images/mine/7ybp) | Crystal structure of FGFR4(V550L) kinase domain with 10z | 分子名称: | Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide | 著者 | Chen, X.J, Lin, Q.M, Chen, Y.H. | 登録日 | 2022-06-29 | 公開日 | 2022-11-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.243 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. J.Med.Chem., 65, 2022
|
|
7YBX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ybx by Molmil](/molmil-images/mine/7ybx) | Crystal structure of FGFR4(V550M) kinase domain with 10z | 分子名称: | Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide | 著者 | Chen, X.J, Lin, Q.M, Chen, Y.H. | 登録日 | 2022-06-30 | 公開日 | 2022-11-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.233 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. J.Med.Chem., 65, 2022
|
|
7F46
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7f46 by Molmil](/molmil-images/mine/7f46) | Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab (state1, local refinement of the RBD, NTD and 35B5 Fab) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 35B5 Fab, Light chain of 35B5 Fab, ... | 著者 | Wang, X.F, Zhu, Y.Q. | 登録日 | 2021-06-17 | 公開日 | 2022-03-23 | 最終更新日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (4.79 Å) | 主引用文献 | A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD Signal Transduct Target Ther, 7, 2022
|
|
6NI2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ni2 by Molmil](/molmil-images/mine/6ni2) | Stabilized beta-arrestin 1-V2T subcomplex of a GPCR-G protein-beta-arrestin mega-complex | 分子名称: | Beta-arrestin-1, Fab30 Heavy Chain, Fab30 Light Chain, ... | 著者 | Nguyen, A.H, Thomsen, A.R.B, Cahill, T.J, des Georges, A, Lefkowitz, R.J. | 登録日 | 2018-12-26 | 公開日 | 2019-11-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure of an endosomal signaling GPCR-G protein-beta-arrestin megacomplex. Nat.Struct.Mol.Biol., 26, 2019
|
|
6NI3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ni3 by Molmil](/molmil-images/mine/6ni3) | B2V2R-Gs protein subcomplex of a GPCR-G protein-beta-arrestin mega-complex | 分子名称: | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Endolysin,Beta-2 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Nguyen, A.H, Thomsen, A.R.B, Cahill, T.J, des Georges, A, Lefkowitz, R.J. | 登録日 | 2018-12-26 | 公開日 | 2019-11-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of an endosomal signaling GPCR-G protein-beta-arrestin megacomplex. Nat.Struct.Mol.Biol., 26, 2019
|
|
6NNJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nnj by Molmil](/molmil-images/mine/6nnj) | |
6NNF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nnf by Molmil](/molmil-images/mine/6nnf) | |
6NM6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nm6 by Molmil](/molmil-images/mine/6nm6) | |
5ZQZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5zqz by Molmil](/molmil-images/mine/5zqz) | Structure of human mitochondrial trifunctional protein, tetramer | 分子名称: | Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta | 著者 | Liang, K, Li, N, Dai, J, Wang, X, Liu, P, Chen, X, Wang, C, Gao, N, Xiao, J. | 登録日 | 2018-04-20 | 公開日 | 2018-06-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Cryo-EM structure of human mitochondrial trifunctional protein Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
5ZRV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5zrv by Molmil](/molmil-images/mine/5zrv) | Structure of human mitochondrial trifunctional protein, octamer | 分子名称: | Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta | 著者 | Liang, K, Li, N, Dai, J, Wang, X, Liu, P, Chen, X, Wang, C, Gao, N, Xiao, J. | 登録日 | 2018-04-25 | 公開日 | 2018-06-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | 主引用文献 | Cryo-EM structure of human mitochondrial trifunctional protein Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
2F4B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2f4b by Molmil](/molmil-images/mine/2f4b) | Crystal structure of the ligand binding domain of human PPAR-gamma in complex with an agonist | 分子名称: | (5-{3-[(6-BENZOYL-1-PROPYL-2-NAPHTHYL)OXY]PROPOXY}-1H-INDOL-1-YL)ACETIC ACID, Peroxisome proliferator-activated receptor gamma | 著者 | Lu, I.L, Peng, Y.H, Mahindroo, N, Hsieh, H.P, Wu, S.Y. | 登録日 | 2005-11-23 | 公開日 | 2006-02-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Indol-1-yl Acetic Acids as Peroxisome Proliferator-Activated Receptor Agonists: Design, Synthesis, Structural Biology, and Molecular Docking Studies J.Med.Chem., 49, 2006
|
|
6NOX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nox by Molmil](/molmil-images/mine/6nox) | Solution structure of SFTI-KLK5 inhibitor | 分子名称: | SFTI-KLK5 Peptide | 著者 | White, A.M. | 登録日 | 2019-01-16 | 公開日 | 2019-04-03 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Amino Acid Scanning at P5' within the Bowman-Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases. J. Med. Chem., 62, 2019
|
|
6M6I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6m6i by Molmil](/molmil-images/mine/6m6i) | Structure of HSV2 B-capsid portal vertex | 分子名称: | Coiled coils chain 1, Coiled coils chain 2, Major capsid protein, ... | 著者 | Wang, X.X, Wang, N. | 登録日 | 2020-03-14 | 公開日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | 主引用文献 | Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation. Protein Cell, 11, 2020
|
|
6M6H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6m6h by Molmil](/molmil-images/mine/6m6h) | Structure of HSV2 C-capsid portal vertex | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | 著者 | Wang, X.X, Wang, N. | 登録日 | 2020-03-14 | 公開日 | 2021-03-24 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation. Protein Cell, 11, 2020
|
|
6M6G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6m6g by Molmil](/molmil-images/mine/6m6g) | Structure of HSV2 viron capsid portal vertex | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Coiled coils, ... | 著者 | Wang, X.X, Wang, N. | 登録日 | 2020-03-14 | 公開日 | 2021-03-24 | 実験手法 | ELECTRON MICROSCOPY (5.39 Å) | 主引用文献 | Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation. Protein Cell, 11, 2020
|
|