6NI3

B2V2R-Gs protein subcomplex of a GPCR-G protein-beta-arrestin mega-complex

Summary for 6NI3

• Entry DOI: 10.2210/pdb6ni3/pdb
• EMDB information: 9375 9376 9377
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, gs protein, signaling transducer, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 163863.31

Authors

Nguyen, A.H.,Thomsen, A.R.B.,Cahill, T.J.,des Georges, A.,Lefkowitz, R.J. (deposition date: 2018-12-26, release date: 2019-11-20, Last modification date: 2019-12-18)

• Primary citation: Nguyen, A.H.,Thomsen, A.R.B.,Cahill 3rd, T.J.,Huang, R.,Huang, L.Y.,Marcink, T.,Clarke, O.B.,Heissel, S.,Masoudi, A.,Ben-Hail, D.,Samaan, F.,Dandey, V.P.,Tan, Y.Z.,Hong, C.,Mahoney, J.P.,Triest, S.,Little 4th, J.,Chen, X.,Sunahara, R.,Steyaert, J.,Molina, H.,Yu, Z.,des Georges, A.,Lefkowitz, R.J.; Structure of an endosomal signaling GPCR-G protein-beta-arrestin megacomplex.; Nat.Struct.Mol.Biol., 26:1123-1131, 2019; PubMed: 31740855; DOI: 10.1038/s41594-019-0330-y

Experimental method

ELECTRON MICROSCOPY (3.8 Å)