6NI3
B2V2R-Gs protein subcomplex of a GPCR-G protein-beta-arrestin mega-complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 380 | 44326.2 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
4 | R | Endolysin,Beta-2 adrenergic receptor chimera | polymer | 506 | 57630.8 | 1 | UniProt (A0A097J809) UniProt (P07550) Pfam (PF00959) Pfam (PF00001) In PDB | Enterobacteria phage RB59 | Lysis protein,Lysozyme,Muramidase,Beta-2 adrenoreceptor,Beta-2 adrenoceptor |
5 | N | Nanobody 35 | polymer | 138 | 15140.7 | 1 | Lama glama (Llama) | ||
6 | R | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one | non-polymer | 370.4 | 1 | Chemie (P0G) |
Sequence modifications
A: 1 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
R: -133 - 26 (UniProt: A0A097J809)
R: 29 - 341 (UniProt: P07550)
PDB | External Database | Details |
---|---|---|
- | Glu 71 | deletion |
- | Gly 72 | deletion |
- | Gly 73 | deletion |
- | Glu 74 | deletion |
- | Glu 75 | deletion |
- | Asp 76 | deletion |
- | Pro 77 | deletion |
- | Gln 78 | deletion |
- | Ala 79 | deletion |
- | Ala 80 | deletion |
- | Arg 81 | deletion |
- | Ser 82 | deletion |
- | Asn 83 | deletion |
- | Ser 84 | deletion |
Ser 86 | Gly 86 | conflict |
PDB | External Database | Details |
---|---|---|
Met -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -164 | - | expression tag |
Lys -163 | - | expression tag |
Thr -162 | - | expression tag |
Ile -161 | - | expression tag |
Ile -160 | - | expression tag |
Ala -159 | - | expression tag |
Leu -158 | - | expression tag |
Ser -157 | - | expression tag |
Tyr -156 | - | expression tag |
Ile -155 | - | expression tag |
Phe -154 | - | expression tag |
Cys -153 | - | expression tag |
Leu -152 | - | expression tag |
Val -151 | - | expression tag |
Phe -150 | - | expression tag |
Ala -149 | - | expression tag |
Asp -148 | - | expression tag |
Tyr -147 | - | expression tag |
Lys -146 | - | expression tag |
Asp -145 | - | expression tag |
Asp -144 | - | expression tag |
Asp -143 | - | expression tag |
Asp -142 | - | expression tag |
Ala -141 | - | expression tag |
Glu -140 | - | expression tag |
Asn -139 | - | expression tag |
Leu -138 | - | expression tag |
Tyr -137 | - | expression tag |
Phe -136 | - | expression tag |
Gln -135 | - | expression tag |
Gly -134 | - | expression tag |
Thr -81 | Cys 54 | conflict |
Ala -38 | Cys 97 | conflict |
Ala 27 | - | linker |
Ala 28 | - | linker |
PDB | External Database | Details |
---|---|---|
Thr 96 | Met 96 | conflict |
Thr 98 | Met 98 | conflict |
Glu 187 | Asn 187 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 163492.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 370.4 | |
All* | Total formula weight | 163863.3 |