6NI2

Stabilized beta-arrestin 1-V2T subcomplex of a GPCR-G protein-beta-arrestin mega-complex

Summary for 6NI2

Entry DOI	10.2210/pdb6ni2/pdb
EMDB information	9375 9376 9377
Descriptor	Nanobody 32, Beta-arrestin-1, Fab30 Heavy Chain, ... (5 entities in total)
Functional Keywords	arrestin, gpcr signaling transducer, scaffolding protein, signaling protein-immune system complex, signaling protein/immune system
Biological source	Lama glama (Llama) More
Total number of polymer chains	5
Total formula weight	110037.85
Authors	Nguyen, A.H.,Thomsen, A.R.B.,Cahill, T.J.,des Georges, A.,Lefkowitz, R.J. (deposition date: 2018-12-26, release date: 2019-11-20, Last modification date: 2019-12-18)
Primary citation	Nguyen, A.H.,Thomsen, A.R.B.,Cahill 3rd, T.J.,Huang, R.,Huang, L.Y.,Marcink, T.,Clarke, O.B.,Heissel, S.,Masoudi, A.,Ben-Hail, D.,Samaan, F.,Dandey, V.P.,Tan, Y.Z.,Hong, C.,Mahoney, J.P.,Triest, S.,Little 4th, J.,Chen, X.,Sunahara, R.,Steyaert, J.,Molina, H.,Yu, Z.,des Georges, A.,Lefkowitz, R.J. Structure of an endosomal signaling GPCR-G protein-beta-arrestin megacomplex. Nat.Struct.Mol.Biol., 26:1123-1131, 2019 Cited by PubMed: 31740855 DOI: 10.1038/s41594-019-0330-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4 Å)

Structure validation