7WCW
Crystal structure of FGFR4(V550L) kinase domain with 7v
Summary for 7WCW
Entry DOI | 10.2210/pdb7wcw/pdb |
Descriptor | Fibroblast growth factor receptor 4, ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, structural protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35467.62 |
Authors | Chen, X.J.,Lin, Q.M.,Dai, S.Y.,Chen, Y.H. (deposition date: 2021-12-20, release date: 2022-03-30, Last modification date: 2023-11-29) |
Primary citation | Shao, M.,Chen, X.,Yang, F.,Song, X.,Zhou, Y.,Lin, Q.,Fu, Y.,Ortega, R.,Lin, X.,Tu, Z.,Patterson, A.V.,Smaill, J.B.,Chen, Y.,Lu, X. Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4. J.Med.Chem., 65:5113-5133, 2022 Cited by PubMed: 35271262DOI: 10.1021/acs.jmedchem.2c00096 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.317 Å) |
Structure validation
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