7F46

Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab (state1, local refinement of the RBD, NTD and 35B5 Fab)

Summary for 7F46

• Entry DOI: 10.2210/pdb7f46/pdb
• EMDB information: 31444
• Descriptor: Spike glycoprotein, Heavy chain of 35B5 Fab, Light chain of 35B5 Fab, ... (4 entities in total)
• Functional Keywords: immune system, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 4
• Total formula weight: 334342.24

Authors

Wang, X.F.,Zhu, Y.Q. (deposition date: 2021-06-17, release date: 2022-03-23, Last modification date: 2022-09-21)

• Primary citation: Wang, X.,Hu, A.,Chen, X.,Zhang, Y.,Yu, F.,Yue, S.,Li, A.,Zhang, J.,Pan, Z.,Yang, Y.,Lin, Y.,Gao, L.,Zhou, J.,Zhao, J.,Li, F.,Shi, Y.,Huang, F.,Yang, X.,Peng, Y.,Tu, L.,Zhang, H.,Zheng, H.,He, J.,Zhang, H.,Xu, L.,Huang, Q.,Zhu, Y.,Deng, K.,Ye, L.; A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD; Signal Transduct Target Ther, 7:114-, 2022; DOI: 10.1038/s41392-022-00954-8

Experimental method

ELECTRON MICROSCOPY (4.79 Å)