7WCX

Crystal structure of FGFR4(V550M) kinase domain with 7v

Summary for 7WCX

• Entry DOI: 10.2210/pdb7wcx/pdb
• Descriptor: Fibroblast growth factor receptor 4, ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, structural protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35581.72

Authors

Chen, X.J.,Lin, Q.M.,Dai, S.Y.,Chen, Y.H. (deposition date: 2021-12-20, release date: 2022-03-30, Last modification date: 2023-11-29)

• Primary citation: Shao, M.,Chen, X.,Yang, F.,Song, X.,Zhou, Y.,Lin, Q.,Fu, Y.,Ortega, R.,Lin, X.,Tu, Z.,Patterson, A.V.,Smaill, J.B.,Chen, Y.,Lu, X.; Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.; J.Med.Chem., 65:5113-5133, 2022; PubMed: 35271262; DOI: 10.1021/acs.jmedchem.2c00096

Experimental method

X-RAY DIFFRACTION (2.175 Å)