2QQJ
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1QSV
| THE VEGF-BINDING DOMAIN OF FLT-1, 20 NMR STRUCTURES | 分子名称: | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 | 著者 | Starovasnik, M.A, Christinger, H.W, Wiesmann, C, Champe, M.A, de Vos, A.M, Skelton, N.J. | 登録日 | 1999-06-23 | 公開日 | 1999-11-10 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states. J.Mol.Biol., 293, 1999
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1QSZ
| THE VEGF-BINDING DOMAIN OF FLT-1 (MINIMIZED MEAN) | 分子名称: | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 | 著者 | Starovasnik, M.A, Christinger, H.W, Wiesmann, C, Champe, M.A, de Vos, A.M, Skelton, N.J. | 登録日 | 1999-06-24 | 公開日 | 1999-11-10 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states. J.Mol.Biol., 293, 1999
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6THP
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2JOA
| HtrA1 bound to an optimized peptide: NMR assignment of PDZ domain and ligand resonances | 分子名称: | Peptide H1-C1, Serine protease HTRA1 | 著者 | Runyon, S.T, Zhang, Y, Appleton, B.A, Sazinksy, S.L, Wu, P, Pan, B, Wiesmann, C, Skelton, N.J, Sidhu, S.S. | 登録日 | 2007-03-01 | 公開日 | 2007-11-20 | 最終更新日 | 2024-05-08 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3 Protein Sci., 16, 2007
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1SHM
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6YN9
| MALT1(329-728) in complex with a sulfonamide containing compound | 分子名称: | 5-[4-[(2,6-diethylphenyl)sulfamoyl]-3-methyl-phenyl]furan-3-carboxylic acid, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 著者 | Renatus, M. | 登録日 | 2020-04-11 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.558 Å) | 主引用文献 | Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity Advanced Therapeutics, 3, 2020
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6YN8
| Human MALT1(334-719) in complex with a tetrazole containing compound | 分子名称: | 3-azanyl-3-methyl-~{N}-[(3~{R})-4-oxidanylidene-5-[[4-[2-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzoxazepin-3-yl]butanamide, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 著者 | Renatus, M. | 登録日 | 2020-04-11 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.052 Å) | 主引用文献 | Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity Advanced Therapeutics, 3, 2020
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7ZYJ
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4U81
| MEK1 Kinase bound to small molecule inhibitor G659 | 分子名称: | 8-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-7-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... | 著者 | Robarge, K.D, Ultsch, M.H, Weismann, C. | 登録日 | 2014-07-31 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | 主引用文献 | Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. Bioorg.Med.Chem.Lett., 24, 2014
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4U80
| MEK 1 kinase bound to G799 | 分子名称: | 3-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)furo[3,2-c]pyridine-2-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... | 著者 | Ultsch, M.H, Robarge, K.D, Weismann, C. | 登録日 | 2014-07-31 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. Bioorg.Med.Chem.Lett., 24, 2014
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8AYH
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1HCF
| Crystal structure of TrkB-d5 bound to neurotrophin-4/5 | 分子名称: | BDNF/NT-3 GROWTH FACTORS RECEPTOR, NEUROTROPHIN-4, SULFATE ION | 著者 | Banfield, M.J, Naylor, R.L, Robertson, A.G.S, Allen, S.J, Dawbarn, D, Brady, R.L. | 登録日 | 2001-05-03 | 公開日 | 2001-12-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Specificity in Trk-Receptor:Neurotrophin Interaction: The Crystal Structure of Trkb-D5 in Complex with Neurotrophin-4/5 Structure, 9, 2001
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6GG0
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4HLE
| Compound 21 (1-alkyl-substituted 1,2,4-triazoles) | 分子名称: | 2-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Murray, J.M, Rouge, L, Wu, P. | 登録日 | 2012-10-16 | 公開日 | 2013-01-09 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase. Bioorg.Med.Chem.Lett., 23, 2013
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4LMN
| Crystal Structure of MEK1 kinase bound to GDC0973 | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Ultsch, M.H. | 登録日 | 2013-07-10 | 公開日 | 2013-08-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature, 501, 2013
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1SI5
| Protease-like domain from 2-chain hepatocyte growth factor | 分子名称: | hepatocyte growth factor | 著者 | Kirchhofer, D, Yao, X, Peek, M, Eigenbrot, C, Lipari, M.T, Billeci, K.L, Maun, H.R, Moran, P, Santell, L, Lazarus, R.A. | 登録日 | 2004-02-27 | 公開日 | 2004-12-28 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling J.Biol.Chem., 279, 2004
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1HE7
| Human Nerve growth factor receptor TrkA | 分子名称: | GLYCEROL, HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR | 著者 | Banfield, M, Robertson, A, Allen, S, Dando, J, Tyler, S, Bennett, G, Brain, S, Mason, G, Holden, P, Clarke, A, Naylor, R, Wilcock, G, Brady, R, Dawbarn, D. | 登録日 | 2000-11-20 | 公開日 | 2001-04-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification and Structure of the Nerve Growth Factor Binding Site on Trka. Biochem.Biophys.Res.Commun., 282, 2001
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6TCZ
| Leishmania tarentolae proteasome 20S subunit complexed with LXE408 | 分子名称: | Proteasome endopeptidase complex, Proteasome subunit alpha type, Proteasome subunit beta, ... | 著者 | Srinivas, H. | 登録日 | 2019-11-07 | 公開日 | 2020-08-26 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases. J.Med.Chem., 63, 2020
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6TD5
| Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib | 分子名称: | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, Proteasome endopeptidase complex, Proteasome subunit alpha type, ... | 著者 | Srinivas, H. | 登録日 | 2019-11-07 | 公開日 | 2020-08-26 | 最終更新日 | 2020-10-21 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases. J.Med.Chem., 63, 2020
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6SJ7
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6UD7
| Crystal structure of full-length human DCAF15-DDB1(deltaBPB)-DDA1-RBM39 in complex with indisulam | 分子名称: | DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1,DNA damage-binding protein 1, ... | 著者 | Bussiere, D.E, Shu, W, Xie, L, Knapp, M. | 登録日 | 2019-09-18 | 公開日 | 2019-12-18 | 最終更新日 | 2020-01-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nat.Chem.Biol., 16, 2020
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6UE5
| Crystal structure of full-length human DCAF15-DDB1-deltaPBP-DDA1-RBM39 in complex with 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide | 分子名称: | 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide, DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, ... | 著者 | Knapp, M.S, Shu, W, Xie, L, Bussiere, D.E. | 登録日 | 2019-09-20 | 公開日 | 2019-12-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nat.Chem.Biol., 16, 2020
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4QYE
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4QYF
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