7ZYJ

Leishmania tarentolae proteasome 20S subunit in complex with compound 2

Summary for 7ZYJ

• Entry DOI: 10.2210/pdb7zyj/pdb
• Related: 6TCZ
• EMDB information: 15025
• Descriptor: Proteasome subunit alpha type, Proteasome subunit beta, Proteasome beta 6 subunit, putative, ... (15 entities in total)
• Functional Keywords: proteasome. cryo-em, inhibitor, hydrolase
• Biological source: Leishmania tarentolae; More
• Total number of polymer chains: 28
• Total formula weight: 807783.63

Authors

Srinivas, H. (deposition date: 2022-05-24, release date: 2022-09-28)

• Primary citation: Koester, D.C.,Marx, V.M.,Williams, S.,Jiricek, J.,Dauphinais, M.,Rene, O.,Miller, S.L.,Zhang, L.,Patra, D.,Chen, Y.L.,Cheung, H.,Gable, J.,Lakshminarayana, S.B.,Osborne, C.,Galarneau, J.R.,Kulkarni, U.,Richmond, W.,Bretz, A.,Xiao, L.,Supek, F.,Wiesmann, C.,Honnappa, S.,Be, C.,Maser, P.,Kaiser, M.,Ritchie, R.,Barrett, M.P.,Diagana, T.T.,Sarko, C.,Rao, S.P.S.; Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT).; J.Med.Chem., 65:11776-11787, 2022; PubMed: 35993839; DOI: 10.1021/acs.jmedchem.2c00791

Experimental method

ELECTRON MICROSCOPY (2.7 Å)