4LMN

Crystal Structure of MEK1 kinase bound to GDC0973

Summary for 4LMN

Entry DOI	10.2210/pdb4lmn/pdb
Related	3V01
Descriptor	Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	kinase, phosphorylation, braf, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: Q02750
Total number of polymer chains	1
Total formula weight	38992.42
Authors	Ultsch, M.H. (deposition date: 2013-07-10, release date: 2013-08-07, Last modification date: 2024-02-28)
Primary citation	Hatzivassiliou, G.,Haling, J.R.,Chen, H.,Song, K.,Price, S.,Heald, R.,Hewitt, J.F.,Zak, M.,Peck, A.,Orr, C.,Merchant, M.,Hoeflich, K.P.,Chan, J.,Luoh, S.M.,Anderson, D.J.,Ludlam, M.J.,Wiesmann, C.,Ultsch, M.,Friedman, L.S.,Malek, S.,Belvin, M. Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature, 501:232-236, 2013 Cited by PubMed: 23934108 DOI: 10.1038/nature12441 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation