4LMN

Crystal Structure of MEK1 kinase bound to GDC0973

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dual specificity mitogen-activated protein kinase kinase 1	polymer	341	37930.6	1	UniProt (Q02750) Pfam (PF00069) In PDB	Homo sapiens (human)	MAP kinase kinase 1, MAPKK 1, MKK1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1
2	A	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	1	Chemie (ANP)
3	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	A	[3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL-PHENYL)AMINO]PHENYL]-[3-OXIDANYL-3-[(2S)-PIPERIDIN-2-YL]AZETIDIN-1-YL]METHANONE	non-polymer		531.3	1	Chemie (EUI)

Sequence modifications

A: 62 - 393 (UniProt: Q02750)

PDB	External Database	Details
Met 61	-	initiating methionine
Leu 394	-	expression tag
Glu 395	-	expression tag
His 396	-	expression tag
His 397	-	expression tag
His 398	-	expression tag
His 399	-	expression tag
His 400	-	expression tag
His 401	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37930.6
Non-Polymers*	Number of molecules	3
	Total formula weight	1061.8
All*	Total formula weight	38992.4

*Water molecules are not included.