1ACM
 
 | | ARGININE 54 IN THE ACTIVE SITE OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE IS CRITICAL FOR CATALYSIS: A SITE-SPECIFIC MUTAGENESIS, NMR AND X-RAY CRYSTALLOGRAPHY STUDY | | 分子名称: | ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN, ... | | 著者 | Stevens, R.C, Kantrowitz, E.R, Lipscomb, W.N. | | 登録日 | 1992-07-08 | | 公開日 | 1992-07-15 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Arginine 54 in the active site of Escherichia coli aspartate transcarbamoylase is critical for catalysis: a site-specific mutagenesis, NMR, and X-ray crystallographic study.
Protein Sci., 1, 1992
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6AT1
 | | STRUCTURAL CONSEQUENCES OF EFFECTOR BINDING TO THE T STATE OF ASPARTATE CARBAMOYLTRANSFERASE. CRYSTAL STRUCTURES OF THE UNLIGATED AND ATP-, AND CTP-COMPLEXED ENZYMES AT 2.6-ANGSTROMS RESOLUTION | | 分子名称: | ASPARTATE CARBAMOYLTRANSFERASE (T STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ... | | 著者 | Stevens, R.C, Gouaux, J.E, Lipscomb, W.N. | | 登録日 | 1990-04-26 | | 公開日 | 1990-10-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution.
Biochemistry, 29, 1990
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1FPI
 | | FRUCTOSE-1,6-BISPHOSPHATASE (D-FRUCTOSE-1,6-BISPHOSPHATE 1-PHOSPHOHYDROLASE) COMPLEXED WITH AMP, 2,5-ANHYDRO-D-GLUCITOL-1,6-BISPHOSPHATE AND POTASSIUM IONS (100 MM) | | 分子名称: | 2,5-anhydro-1,6-di-O-phosphono-D-glucitol, ADENOSINE MONOPHOSPHATE, FRUCTOSE-1,6-BISPHOSPHATASE, ... | | 著者 | Villeret, V, Lipscomb, W.N. | | 登録日 | 1995-06-02 | | 公開日 | 1996-06-20 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystallographic evidence for the action of potassium, thallium, and lithium ions on fructose-1,6-bisphosphatase.
Proc.Natl.Acad.Sci.USA, 92, 1995
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8AT1
 | | CRYSTAL STRUCTURES OF ASPARTATE CARBAMOYLTRANSFERASE LIGATED WITH PHOSPHONOACETAMIDE, MALONATE, AND CTP OR ATP AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H | | 分子名称: | ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ... | | 著者 | Gouaux, J.E, Stevens, R.C, Lipscomb, W.N. | | 登録日 | 1989-09-22 | | 公開日 | 1990-10-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990
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3G3N
 | | PDE7A catalytic domain in complex with 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one | | 分子名称: | 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one, High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, MAGNESIUM ION, ... | | 著者 | Castano, T, Wang, H. | | 登録日 | 2009-02-02 | | 公開日 | 2009-04-28 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors
Chemmedchem, 4, 2009
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3B2R
 | | Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil | | 分子名称: | 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, cGMP-specific 3',5'-cyclic phosphodiesterase | | 著者 | Huanchen, W, Mengchun, Y, Howard, R, Sharron, H.F, Hengming, K. | | 登録日 | 2007-10-19 | | 公開日 | 2008-05-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.
Mol.Pharmacol., 73, 2008
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5AT1
 | | STRUCTURAL CONSEQUENCES OF EFFECTOR BINDING TO THE T STATE OF ASPARTATE CARBAMOYLTRANSFERASE. CRYSTAL STRUCTURES OF THE UNLIGATED AND ATP-, AND CTP-COMPLEXED ENZYMES AT 2.6-ANGSTROMS RESOLUTION | | 分子名称: | ASPARTATE CARBAMOYLTRANSFERASE (T STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ... | | 著者 | Stevens, R.C, Gouaux, J.E, Lipscomb, W.N. | | 登録日 | 1990-04-26 | | 公開日 | 1990-10-15 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution.
Biochemistry, 29, 1990
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2OUR
 | | crystal structure of PDE10A2 mutant D674A in complex with cAMP | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, MAGNESIUM ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | | 著者 | Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H. | | 登録日 | 2007-02-12 | | 公開日 | 2007-03-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2OUU
 | | crystal structure of PDE10A2 mutant D674A in complex with cGMP | | 分子名称: | GUANOSINE-3',5'-MONOPHOSPHATE, MAGNESIUM ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | | 著者 | Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H. | | 登録日 | 2007-02-12 | | 公開日 | 2007-03-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2OUS
 | | crystal structure of PDE10A2 mutant D674A | | 分子名称: | MAGNESIUM ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | | 著者 | Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H. | | 登録日 | 2007-02-12 | | 公開日 | 2007-03-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2OUV
 | | crystal structure of pde10a2 mutant of D564N | | 分子名称: | MAGNESIUM ION, ZINC ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | | 著者 | Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H. | | 登録日 | 2007-02-12 | | 公開日 | 2007-03-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2OUY
 | | crystal structure of pde10a2 mutant D564A in complex with cAMP. | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, MAGNESIUM ION, ZINC ION, ... | | 著者 | Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H. | | 登録日 | 2007-02-12 | | 公開日 | 2007-03-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2OUQ
 | | crystal structure of PDE10A2 in complex with GMP | | 分子名称: | GUANOSINE-5'-MONOPHOSPHATE, MAGNESIUM ION, ZINC ION, ... | | 著者 | Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H. | | 登録日 | 2007-02-12 | | 公開日 | 2007-03-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2OUP
 | | crystal structure of PDE10A | | 分子名称: | MAGNESIUM ION, ZINC ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | | 著者 | Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H. | | 登録日 | 2007-02-12 | | 公開日 | 2007-03-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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7AT1
 | | CRYSTAL STRUCTURES OF ASPARTATE CARBAMOYLTRANSFERASE LIGATED WITH PHOSPHONOACETAMIDE, MALONATE, AND CTP OR ATP AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ... | | 著者 | Gouaux, J.E, Stevens, R.C, Lipscomb, W.N. | | 登録日 | 1989-09-22 | | 公開日 | 1990-10-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH.
Biochemistry, 29, 1990
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6CFE
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6CBU
 | | Crystal structure of C4S3: A computationally designed immunogen to target Carbohydrate-Occluded Epitopes on the HIV envelope | | 分子名称: | Acylphosphatase-1, SULFATE ION | | 著者 | Zhu, C, Ke, H.M, Swanstrom, R, Dokholyan, N.V. | | 登録日 | 2018-02-05 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies.
Nat Commun, 10, 2019
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5ED9
 | | Crystal structure of CC1 of mouse SUN2 | | 分子名称: | SUN domain-containing protein 2 | | 著者 | Nie, S, Ke, H.M, Gao, F, Ren, J.Q, Wang, M.Z, Huo, L, Gong, W.M, Feng, W. | | 登録日 | 2015-10-21 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.009 Å) | | 主引用文献 | Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators
Structure, 24, 2016
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5ED8
 | | Crystal structure of CC2-SUN of mouse SUN2 | | 分子名称: | MAGNESIUM ION, MKIAA0668 protein | | 著者 | Nie, S, Ke, H.M, Gao, F, Ren, J.Q, Wang, M.Z, Huo, L, Gong, W.M, Feng, W. | | 登録日 | 2015-10-21 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators
Structure, 24, 2016
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1EV7
 | | CRYSTAL STRUCTURE OF DNA RESTRICTION ENDONUCLEASE NAEI | | 分子名称: | TYPE IIE RESTRICTION ENDONUCLEASE NAEI | | 著者 | Huai, Q, Colandene, J.D, Chen, Y, Luo, F, Zhao, Y. | | 登録日 | 2000-04-19 | | 公開日 | 2000-10-19 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | Crystal structure of NaeI-an evolutionary bridge between DNA endonuclease and topoisomerase.
EMBO J., 19, 2000
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7YP0
 | | Crystal structure of CtGST | | 分子名称: | Glutathione S-transferase | | 著者 | Yang, J, Fan, J.P, Lei, X.G. | | 登録日 | 2022-08-02 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Enzymatic Degradation of Deoxynivalenol with the Engineered Detoxification Enzyme Fhb7.
Jacs Au, 4, 2024
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7YOC
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4MD6
 | | Crystal structure of PDE5 in complex with inhibitor 5R | | 分子名称: | 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one, MAGNESIUM ION, SULFATE ION, ... | | 著者 | Cui, W, Huang, M, Shao, Y, Luo, H. | | 登録日 | 2013-08-22 | | 公開日 | 2014-07-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure.
Biochem Pharmacol, 89, 2014
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1FSA
 | | THE T-STATE STRUCTURE OF LYS 42 TO ALA MUTANT OF THE PIG KIDNEY FRUCTOSE 1,6-BISPHOSPHATASE EXPRESSED IN E. COLI | | 分子名称: | 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, FRUCTOSE 1,6-BISPHOSPHATASE, ... | | 著者 | Lu, G, Stec, B, Giroux, E, Kantrowitz, E.R. | | 登録日 | 1996-08-24 | | 公開日 | 1997-09-04 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Evidence for an active T-state pig kidney fructose 1,6-bisphosphatase: interface residue Lys-42 is important for allosteric inhibition and AMP cooperativity.
Protein Sci., 5, 1996
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1PA4
 | | Solution structure of a putative ribosome-binding factor from Mycoplasma pneumoniae (MPN156) | | 分子名称: | Probable ribosome-binding factor A | | 著者 | Rubin, S.M, Pelton, J.G, Yokota, H, Kim, R, Wemmer, D.E, Berkeley Structural Genomics Center (BSGC) | | 登録日 | 2003-05-13 | | 公開日 | 2004-03-02 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a putative ribosome binding protein from Mycoplasma pneumoniae and comparison to a distant homolog.
J.STRUCT.FUNCT.GENOM., 4, 2003
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