2OUU

crystal structure of PDE10A2 mutant D674A in complex with cGMP

Summary for 2OUU

Entry DOI	10.2210/pdb2ouu/pdb
Related	2OUN 2OUP 2OUQ 2OUR 2OUS 2OUV 2OUY
Descriptor	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, MAGNESIUM ION, GUANOSINE-3',5'-MONOPHOSPHATE, ... (4 entities in total)
Functional Keywords	pde, cgmp, substrate specificity, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9Y233
Total number of polymer chains	2
Total formula weight	77608.36
Authors	Wang, H.C.,Liu, Y.D.,Hou, J.,Zheng, M.Y.,Robinson, H. (deposition date: 2007-02-12, release date: 2007-03-20, Last modification date: 2024-04-03)
Primary citation	Wang, H.,Liu, Y.,Hou, J.,Zheng, M.,Robinson, H.,Ke, H. From the Cover: Structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa, 104:5782-5787, 2007 Cited by PubMed: 17389385 DOI: 10.1073/pnas.0700279104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation