2OUU
crystal structure of PDE10A2 mutant D674A in complex with cGMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 331 | 38262.1 | 2 | UniProt (Q9Y233) | Homo sapiens (human) | |
| 2 | C, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, E, F (A) | GUANOSINE-3',5'-MONOPHOSPHATE | non-polymer | 345.2 | 3 | Chemie (35G) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 366 | Chemie (HOH) |
Sequence modifications
A, B: 449 - 776 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| Ser 446 | - | cloning artifact |
| His 447 | - | cloning artifact |
| Met 448 | - | cloning artifact |
| Ala 674 | Asp 664 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76524.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1084.2 | |
| All* | Total formula weight | 77608.4 |
