3G3N

PDE7A catalytic domain in complex with 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one

Summary for 3G3N

Entry DOI	10.2210/pdb3g3n/pdb
Descriptor	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one, ZINC ION, ... (4 entities in total)
Functional Keywords	pde7, crystal, inhibitor complex, alternative splicing, camp, hydrolase, phosphoprotein
Biological source	Homo sapiens (human)
Cellular location	Isoform PDE7A1: Cytoplasm, cytosol. Isoform PDE7A2: Cytoplasm: Q13946
Total number of polymer chains	1
Total formula weight	37293.16
Authors	Castano, T.,Wang, H. (deposition date: 2009-02-02, release date: 2009-04-28, Last modification date: 2024-02-21)
Primary citation	Castano, T.,Wang, H.,Campillo, N.E.,Ballester, S.,Gonzalez-Garcia, C.,Hernandez, J.,Perez, C.,Cuenca, J.,Perez-Castillo, A.,Martinez, A.,Huertas, O.,Gelpi, J.L.,Luque, F.J.,Ke, H.,Gil, C. Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors Chemmedchem, 4:866-876, 2009 Cited by PubMed: 19350606 DOI: 10.1002/cmdc.200900043 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation