3G3N

PDE7A catalytic domain in complex with 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE TC8 A 3

Chain	Residue
A	ILE323
A	ILE363
A	PHE384
A	LYS393
A	TYR394
A	LEU401
A	PHE416

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	ASP253
A	ASP362
A	HIS216
A	HIS252

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 2

Chain	Residue
A	ASP253
A	GLU282

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHpGvnQpF

Chain	Residue	Details
A	HIS252-PHE263

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15994308","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19350606","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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