5IC3
 
 | | CAL PDZ domain with peptide and inhibitor | | 分子名称: | 4-[methyl(nitroso)amino]benzene-1,2-diol, Golgi-associated PDZ and coiled-coil motif-containing protein, HPV18E6 Peptide | | 著者 | Zhao, Y, Madden, D.R. | | 登録日 | 2016-02-22 | | 公開日 | 2017-08-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | CAL PDZ domain with peptide and inhibitor
To Be Published
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8GXI
 | | The crystal structure of SARS-CoV-2 main protease in complex with 14c | | 分子名称: | 3C-like proteinase nsp5, N-[(2S)-3-cyclohexyl-1-[[(2S,3R)-4-(cyclopropylamino)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]butan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-benzofuran-2-carboxamide | | 著者 | Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z. | | 登録日 | 2022-09-20 | | 公開日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | The crystal structure of SARS-CoV-2 main protease in complex with 14c
To Be Published
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8GX3
 | | The crystal structure of human Calpain-1 protease core in complex with 14c | | 分子名称: | CALCIUM ION, Calpain-1 catalytic subunit, N-[(2S)-3-cyclohexyl-1-[[(2S,3S)-4-(cyclopropylamino)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]butan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-benzofuran-2-carboxamide | | 著者 | Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z. | | 登録日 | 2022-09-18 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | The crystal structure of human Calpain-1 protease core in complex with 14c
To Be Published
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8GXH
 | | The crystal structure of SARS-CoV-2 main protease in complex with 14b | | 分子名称: | 3C-like proteinase nsp5, N-[(2S)-3-cyclohexyl-1-oxidanylidene-1-[[(2S,3R)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide | | 著者 | Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z. | | 登録日 | 2022-09-20 | | 公開日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | The crystal structure of SARS-CoV-2 main protease in complex with 14b
To Be Published
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8GX2
 | | The crystal structure of human CtsL in complex with 14c | | 分子名称: | DIMETHYL SULFOXIDE, N-[(2S)-3-cyclohexyl-1-[[(2S,3S)-4-(cyclopropylamino)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]butan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-benzofuran-2-carboxamide, Procathepsin L | | 著者 | Zhao, Y, Shao, M, Zhao, J, Yang, H, Rao, Z. | | 登録日 | 2022-09-18 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The crystal structure of human CtsL in complex with 14a
To Be Published
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8GXG
 | | The crystal structure of SARS-CoV-2 main protease in complex with 14a | | 分子名称: | 3C-like proteinase nsp5, N-[(2S)-3-(4-fluorophenyl)-1-oxidanylidene-1-[[(2S,3S)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide | | 著者 | Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z. | | 登録日 | 2022-09-20 | | 公開日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | The crystal structure of SARS-CoV-2 main protease in complex with 14a
To Be Published
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7VH8
 | | Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332 | | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase, DIMETHYL SULFOXIDE | | 著者 | Zhao, Y, Zhang, Q, Yang, H, Rao, Z. | | 登録日 | 2021-09-21 | | 公開日 | 2021-11-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332.
Protein Cell, 13, 2022
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5ZG9
 | | Crystal structure of MoSub1-ssDNA complex in phosphate buffer | | 分子名称: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*G)-3'), MoSub1, PHOSPHATE ION | | 著者 | Zhao, Y, Huang, J, Liu, H, Yi, L, Wang, S, Zhang, X, Liu, J. | | 登録日 | 2018-03-08 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | The effect of phosphate ion on the ssDNA binding mode of MoSub1, a Sub1/PC4 homolog from rice blast fungus.
Proteins, 87, 2019
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8H3T
 | | The crystal structure of AlpH | | 分子名称: | AlpH, GLYCEROL | | 著者 | Zhao, Y, Li, M, Jiang, M, Pan, L.F. | | 登録日 | 2022-10-09 | | 公開日 | 2023-09-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.866 Å) | | 主引用文献 | O-methyltransferase-like enzyme catalyzed diazo installation in polyketide biosynthesis.
Nat Commun, 14, 2023
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4Q4F
 | | Crystal structure of LIMP-2 (space group C2) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-O-phosphono-beta-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Ren, J, Padilla-Parra, S, Fry, L.E, Stuart, D.I. | | 登録日 | 2014-04-14 | | 公開日 | 2014-07-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Lysosome sorting of beta-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor.
Nat Commun, 5, 2014
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4Q4B
 | | Crystal structure of LIMP-2 (space group C2221) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Lysosome membrane protein 2, ... | | 著者 | Zhao, Y, Ren, J, Padilla-Parra, S, Fry, L.E, Stuart, D.I. | | 登録日 | 2014-04-14 | | 公開日 | 2014-07-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | | 主引用文献 | Lysosome sorting of beta-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor.
Nat Commun, 5, 2014
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5WSZ
 | | Crystal structure of a lytic polysaccharide monooxygenase,BtLPMO10A, from Bacillus thuringiensis | | 分子名称: | COPPER (II) ION, LpmO10A | | 著者 | Zhao, Y, Zhang, H, Yin, H. | | 登録日 | 2016-12-08 | | 公開日 | 2017-02-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.565 Å) | | 主引用文献 | Crystal structure of a lytic polysaccharide monooxygenase,BtLPMO10A, from Bacillus thuringiensis
To Be Published
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7D7L
 | | The crystal structure of SARS-CoV-2 papain-like protease in complex with YM155 | | 分子名称: | 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione, CAFFEINE, GLYCEROL, ... | | 著者 | Zhao, Y, Sun, L, Yang, H.T, Rao, Z.H. | | 登録日 | 2020-10-04 | | 公開日 | 2021-04-21 | | 最終更新日 | 2021-11-17 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors.
Protein Cell, 12, 2021
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7D7K
 | | The crystal structure of SARS-CoV-2 papain-like protease in apo form | | 分子名称: | 1,2-ETHANEDIOL, CAFFEINE, Non-structural protein 3, ... | | 著者 | Zhao, Y, Sun, L, Yang, H.T, Rao, Z.H. | | 登録日 | 2020-10-04 | | 公開日 | 2021-04-21 | | 最終更新日 | 2021-11-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors.
Protein Cell, 12, 2021
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7X31
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7W34
 | | The crystal structure of human CtsL in complex with 14b | | 分子名称: | N-[(2S)-3-cyclohexyl-1-oxidanylidene-1-[[(2S,3S)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide, Procathepsin L | | 著者 | Zhao, Y, Shao, M, Zhao, J, Yang, H, Rao, Z. | | 登録日 | 2021-11-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | The crystal structure of human CtsL in complex with 14a
To Be Published
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7W33
 | | The crystal structure of human CtsL in complex with 14a | | 分子名称: | N-[(2S)-3-(4-fluorophenyl)-1-oxidanylidene-1-[[(2R,3S)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide, Procathepsin L | | 著者 | Zhao, Y, Shao, M, Zhao, J, Yang, H, Rao, Z. | | 登録日 | 2021-11-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | The crystal structure of human CtsL in complex with 14a
To Be Published
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7W7O
 | | The crystal structure of human Calpain-1 protease core in complex with 14a | | 分子名称: | CALCIUM ION, Calpain-1 catalytic subunit, HYDROSULFURIC ACID, ... | | 著者 | Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z. | | 登録日 | 2021-12-06 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | The crystal structure of human Calpain-1 protease core in complex with 14a
To Be Published
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7X79
 | | The crystal structure of human Calpain-1 protease core in complex with 14b | | 分子名称: | CALCIUM ION, Calpain-1 catalytic subunit, HYDROSULFURIC ACID, ... | | 著者 | Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z. | | 登録日 | 2022-03-09 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The crystal structure of human Calpain-1 protease core in complex with 14a
To Be Published
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6JP5
 | | Rabbit Cav1.1-Nifedipine Complex | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Huang, G, Wu, J, Yan, N. | | 登録日 | 2019-03-25 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel.
Cell, 177, 2019
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6JP8
 | | Rabbit Cav1.1-Bay K8644 Complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Huang, G, Wu, J, Yan, N. | | 登録日 | 2019-03-26 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel.
Cell, 177, 2019
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6JPB
 | | Rabbit Cav1.1-Diltiazem Complex | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Huang, G, Wu, J, Yan, N. | | 登録日 | 2019-03-26 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel.
Cell, 177, 2019
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6JPA
 | | Rabbit Cav1.1-Verapamil Complex | | 分子名称: | (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Zhao, Y, Huang, G, Wu, J, Yan, N. | | 登録日 | 2019-03-26 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel.
Cell, 177, 2019
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7B8M
 | | Notum-Fragment 193 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-methoxy-2-(1~{H}-pyrazol-3-yl)phenol, ... | | 著者 | Zhao, Y, Jonees, E.Y. | | 登録日 | 2020-12-13 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits.
Acs Chem Neurosci, 13, 2022
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7B8L
 | | Notum-Fragment 174 | | 分子名称: | 1,2-ETHANEDIOL, 2,4-bis(fluoranyl)-6-(1~{H}-pyrazol-3-yl)phenol, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jonees, E.Y. | | 登録日 | 2020-12-13 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits.
Acs Chem Neurosci, 13, 2022
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