7VH8

Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332

Summary for 7VH8

• Entry DOI: 10.2210/pdb7vh8/pdb
• Descriptor: 3C-like proteinase, (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: sars-cov-2, main protease, pf-07321332, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV,SARS-CoV-2)
• Total number of polymer chains: 1
• Total formula weight: 34405.22

Authors

Zhao, Y.,Zhang, Q.,Yang, H.,Rao, Z. (deposition date: 2021-09-21, release date: 2021-11-03, Last modification date: 2023-11-29)

• Primary citation: Zhao, Y.,Fang, C.,Zhang, Q.,Zhang, R.,Zhao, X.,Duan, Y.,Wang, H.,Zhu, Y.,Feng, L.,Zhao, J.,Shao, M.,Yang, X.,Zhang, L.,Peng, C.,Yang, K.,Ma, D.,Rao, Z.,Yang, H.; Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332.; Protein Cell, 13:689-693, 2022; PubMed: 34687004; DOI: 10.1007/s13238-021-00883-2

Experimental method

X-RAY DIFFRACTION (1.59 Å)