7VH8
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332
Summary for 7VH8
Entry DOI | 10.2210/pdb7vh8/pdb |
Descriptor | 3C-like proteinase, (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | sars-cov-2, main protease, pf-07321332, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV,SARS-CoV-2) |
Total number of polymer chains | 1 |
Total formula weight | 34405.22 |
Authors | |
Primary citation | Zhao, Y.,Fang, C.,Zhang, Q.,Zhang, R.,Zhao, X.,Duan, Y.,Wang, H.,Zhu, Y.,Feng, L.,Zhao, J.,Shao, M.,Yang, X.,Zhang, L.,Peng, C.,Yang, K.,Ma, D.,Rao, Z.,Yang, H. Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332. Protein Cell, 13:689-693, 2022 Cited by PubMed: 34687004DOI: 10.1007/s13238-021-00883-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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