5VHE
 
 | | DHX36 in complex with the c-Myc G-quadruplex | | 分子名称: | DEAH (Asp-Glu-Ala-His) box polypeptide 36, DNA (5'-D(*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*TP*TP*TP*TP*TP*T)-3'), POTASSIUM ION | | 著者 | Chen, M, Ferre-D'Amare, A. | | 登録日 | 2017-04-13 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.793 Å) | | 主引用文献 | Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Nature, 558, 2018
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7CMC
 | | CRYSTAL STRUCTURE OF DEOXYHYPUSINE SYNTHASE FROM PYROCOCCUS HORIKOSHII | | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Probable deoxyhypusine synthase | | 著者 | Yu, J, Gai, Z.Q, Okada, C, Yao, M. | | 登録日 | 2020-07-27 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Flexible NAD+Binding in Deoxyhypusine Synthase Reflects the Dynamic Hypusine Modification of Translation Factor IF5A.
Int J Mol Sci, 21, 2020
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3BWH
 | | Atomic resolution structure of cucurmosin, a novel type 1 RIP from the sarcocarp of Cucurbita moschata | | 分子名称: | 1,2-ETHANEDIOL, PHOSPHATE ION, beta-D-xylopyranose-(1-2)-[alpha-D-mannopyranose-(1-3)][alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Chen, L. | | 登録日 | 2008-01-09 | | 公開日 | 2008-10-07 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | Atomic resolution structure of cucurmosin, a novel type 1 ribosome-inactivating protein from the sarcocarp of Cucurbita moschata.
J.Struct.Biol., 164, 2008
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3CHQ
 | | Crystal structure of leukotriene a4 hydrolase in complex with N5-[4-(phenylmethoxy)phenyl]-L-glutamine | | 分子名称: | (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid, IMIDAZOLE, Leukotriene A-4 hydrolase, ... | | 著者 | Thunnissen, M.M.G.M, Adler, M, Whitlow, M. | | 登録日 | 2008-03-10 | | 公開日 | 2008-04-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorg.Med.Chem., 16, 2008
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7TCQ
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3BZU
 | | Crystal structure of human 11-beta-hydroxysteroid dehydrogenase(HSD1) in complex with NADP and thiazolone inhibitor | | 分子名称: | (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Min, X, Sudom, A, Xu, H, Wang, Z, Walker, N.P. | | 登録日 | 2008-01-18 | | 公開日 | 2008-06-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.
Chem.Biol.Drug Des., 71, 2008
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4N6J
 | | Crystal structure of human Striatin-3 coiled coil domain | | 分子名称: | Striatin-3 | | 著者 | Chen, C, Shi, Z, Zhou, Z. | | 登録日 | 2013-10-13 | | 公開日 | 2014-02-26 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | | 主引用文献 | Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex.
J.Biol.Chem., 289, 2014
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2RBE
 | | The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors | | 分子名称: | (5R)-2-[(2-fluorophenyl)amino]-5-(1-methylethyl)-1,3-thiazol-4(5H)-one, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Zhang, J, Jordan, S.R, Li, V. | | 登録日 | 2007-09-18 | | 公開日 | 2008-01-15 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
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4XH3
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5X9C
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5X9B
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8WD8
 | | Cryo-EM structure of TtdAgo-guide DNA-target DNA complex | | 分子名称: | Argonaute family protein, Guide DNA, MAGNESIUM ION, ... | | 著者 | Zhuang, L. | | 登録日 | 2023-09-14 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute.
Mol.Cell, 84, 2024
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6WL5
 | | Crystal structure of EcmrR C-terminal domain | | 分子名称: | 1,2-ETHANEDIOL, CETYL-TRIMETHYL-AMMONIUM, CHLORIDE ION, ... | | 著者 | Yang, Y, Liu, C, Liu, B. | | 登録日 | 2020-04-18 | | 公開日 | 2021-04-07 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural visualization of transcription activated by a multidrug-sensing MerR family regulator.
Nat Commun, 12, 2021
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6XCL
 | | Crystal Structure of human telomeric DNA G-quadruplex in complex with a novel platinum(II) complex. | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3'), POTASSIUM ION, ... | | 著者 | Miron, C.E, van Staalduinen, L.M, Jia, Z, Petitjean, A. | | 登録日 | 2020-06-08 | | 公開日 | 2020-11-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution- and Solid-State Investigations.
Angew.Chem.Int.Ed.Engl., 60, 2021
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4N9G
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8HK7
 | | Structure of PKD2-F604P (Polycystin-2, TRPP2) with ML-SA1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, CALCIUM ION, ... | | 著者 | Chen, M.Y, Su, Q, Wang, Z.F, Yu, Y. | | 登録日 | 2022-11-25 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands.
Proc.Natl.Acad.Sci.USA, 121, 2024
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6WMW
 | | GFRAL receptor bound with two antibody Fabs (3P10, 25M22) | | 分子名称: | FAB25M22 heavy chain fragment, FAB25M22 light chain, FAB3P10 heavy chain fragment, ... | | 著者 | White, A, Lakshminarasimhan, D, Olland, A, Suto, R.K. | | 登録日 | 2020-04-21 | | 公開日 | 2020-07-15 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.
Nat Med, 26, 2020
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6DWA
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6DWC
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6DW2
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6DWI
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8ETR
 | | CryoEM Structure of NLRP3 NACHT domain in complex with G2394 | | 分子名称: | (6S,8R)-N-[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl]-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Murray, J.M, Johnson, M.C. | | 登録日 | 2022-10-17 | | 公開日 | 2022-11-02 | | 最終更新日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Overcoming Preclinical Safety Obstacles to Discover ( S )- N -((1,2,3,5,6,7-Hexahydro- s -indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H -pyrazolo[5,1- b ][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.
J.Med.Chem., 65, 2022
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5K6G
 | | Crystal structure of prefusion-stabilized RSV F single-chain 9-24 DS-Cav1 variant. | | 分子名称: | Fusion glycoprotein F0,Fusion glycoprotein F0 | | 著者 | Joyce, M.G, Zhang, B, Mascola, J.R, Kwong, P.D. | | 登録日 | 2016-05-24 | | 公開日 | 2016-09-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.
Nat.Struct.Mol.Biol., 23, 2016
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5K6F
 | | Crystal structure of prefusion-stabilized RSV F single-chain 9-19 DS-Cav1 variant. | | 分子名称: | Fusion glycoprotein F0 | | 著者 | Joyce, M.G, Zhang, B, Lai, Y.T, Mascola, J.R, Kwong, P.D. | | 登録日 | 2016-05-24 | | 公開日 | 2016-08-10 | | 最終更新日 | 2016-09-21 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.
Nat.Struct.Mol.Biol., 23, 2016
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5K6B
 | | Crystal structure of prefusion-stabilized RSV F single-chain 9 DS-Cav1 variant. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, SULFATE ION | | 著者 | Joyce, M.G, Zhang, B, Rundlet, E.J, Mascola, J.R, Kwong, P.D. | | 登録日 | 2016-05-24 | | 公開日 | 2016-08-31 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.981 Å) | | 主引用文献 | Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.
Nat.Struct.Mol.Biol., 23, 2016
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