Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9

Summary for 4N9G

DescriptorAntibody 17HD9, Heavy Chain, Antibody 17HD9, Light Chain, Epitope Scaffold rsv_1isea_FFL_001_C, ... (4 entities in total)
Functional Keywordsantibody, hairpin, epitope scaffold, immune system
Biological sourceMacaca mulatta
Total number of polymer chains12
Total molecular weight249699.92
Carrico, C.T.D.,Strong, R.K. (deposition date: 2013-10-21, release date: 2014-02-12)
Primary citation
Correia, B.E.,Bates, J.T.,Loomis, R.J.,Baneyx, G.,Carrico, C.,Jardine, J.G.,Rupert, P.,Correnti, C.,Kalyuzhniy, O.,Vittal, V.,Connell, M.J.,Stevens, E.,Schroeter, A.,Chen, M.,Macpherson, S.,Serra, A.M.,Adachi, Y.,Holmes, M.A.,Li, Y.,Klevit, R.E.,Graham, B.S.,Wyatt, R.T.,Baker, D.,Strong, R.K.,Crowe, J.E.,Johnson, P.R.,Schief, W.R.
Proof of principle for epitope-focused vaccine design.
Nature, 507:201-206, 2014
PubMed: 24499818 (PDB entries with the same primary citation)
DOI: 10.1038/nature12966
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.30070.3%3.6%6.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution