6XCL

Crystal Structure of human telomeric DNA G-quadruplex in complex with a novel platinum(II) complex.

Summary for 6XCL

• Entry DOI: 10.2210/pdb6xcl/pdb
• Descriptor: DNA (5'-D(*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3'), Platinum(II) bis[3-(pyridin-2-yl)-[1,2,4]triazolo[4,3-a]pyridine], 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: guanine quadruplex, ligand complex, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 16049.10

Authors

Miron, C.E.,van Staalduinen, L.M.,Jia, Z.,Petitjean, A. (deposition date: 2020-06-08, release date: 2020-11-04, Last modification date: 2023-10-18)

• Primary citation: Miron, C.E.,van Staalduinen, L.,Rangaswamy, A.M.,Chen, M.,Liang, Y.,Jia, Z.,Mergny, J.L.,Petitjean, A.; Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution- and Solid-State Investigations.; Angew.Chem.Int.Ed.Engl., 60:2500-2507, 2021; PubMed: 33090592; DOI: 10.1002/anie.202012520

Experimental method

X-RAY DIFFRACTION (2.7 Å)