3BZU

Crystal structure of human 11-beta-hydroxysteroid dehydrogenase(HSD1) in complex with NADP and thiazolone inhibitor

Summary for 3BZU

• Entry DOI: 10.2210/pdb3bzu/pdb
• Related: 1xu9
• Descriptor: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one, ... (4 entities in total)
• Functional Keywords: 11beta hydroxysteroid dehydrogenase, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, microsome, nadp, oxidoreductase, signal-anchor, steroid metabolism, transmembrane
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
• Total number of polymer chains: 4
• Total formula weight: 131602.34

Authors

Min, X.,Sudom, A.,Xu, H.,Wang, Z.,Walker, N.P. (deposition date: 2008-01-18, release date: 2008-06-10, Last modification date: 2024-02-21)

• Primary citation: Hale, C.,Veniant, M.,Wang, Z.,Chen, M.,McCormick, J.,Cupples, R.,Hickman, D.,Min, X.,Sudom, A.,Xu, H.,Matsumoto, G.,Fotsch, C.,St Jean, D.J.,Wang, M.; Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.; Chem.Biol.Drug Des., 71:36-44, 2008; PubMed: 18069989; DOI: 10.1111/j.1747-0285.2007.00603.x

Experimental method

X-RAY DIFFRACTION (2.25 Å)