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2RBE

The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors

Summary for 2RBE
Entry DOI10.2210/pdb2rbe/pdb
DescriptorCorticosteroid 11-beta-dehydrogenase isozyme 1, (5R)-2-[(2-fluorophenyl)amino]-5-(1-methylethyl)-1,3-thiazol-4(5H)-one, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywordsalpha beta, 3-layer(aba) sandwich, rossmann fold, nad(p)-binding rossmann-like domain, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, microsome, nadp, oxidoreductase, signal-anchor, steroid metabolism, transmembrane, polymorphism
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845
Total number of polymer chains4
Total formula weight125936.62
Authors
Zhang, J.,Jordan, S.R.,Li, V. (deposition date: 2007-09-18, release date: 2008-01-15, Last modification date: 2024-02-21)
Primary citationYuan, C.,St Jean, D.J.,Liu, Q.,Cai, L.,Li, A.,Han, N.,Moniz, G.,Askew, B.,Hungate, R.W.,Johansson, L.,Tedenborg, L.,Pyring, D.,Williams, M.,Hale, C.,Chen, M.,Cupples, R.,Zhang, J.,Jordan, S.,Bartberger, M.D.,Sun, Y.,Emery, M.,Wang, M.,Fotsch, C.
The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.
Bioorg.Med.Chem.Lett., 17:6056-6061, 2007
Cited by
PubMed: 17919905
DOI: 10.1016/j.bmcl.2007.09.070
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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