6WMW
GFRAL receptor bound with two antibody Fabs (3P10, 25M22)
Summary for 6WMW
Entry DOI | 10.2210/pdb6wmw/pdb |
Descriptor | GDNF family receptor alpha-like, FAB3P10 heavy chain fragment, FAB3P10 light chain, ... (5 entities in total) |
Functional Keywords | receptor, signaling, antibodes, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 127057.10 |
Authors | White, A.,Lakshminarasimhan, D.,Olland, A.,Suto, R.K. (deposition date: 2020-04-21, release date: 2020-07-15, Last modification date: 2023-10-18) |
Primary citation | Suriben, R.,Chen, M.,Higbee, J.,Oeffinger, J.,Ventura, R.,Li, B.,Mondal, K.,Gao, Z.,Ayupova, D.,Taskar, P.,Li, D.,Starck, S.R.,Chen, H.H.,McEntee, M.,Katewa, S.D.,Phung, V.,Wang, M.,Kekatpure, A.,Lakshminarasimhan, D.,White, A.,Olland, A.,Haldankar, R.,Solloway, M.J.,Hsu, J.Y.,Wang, Y.,Tang, J.,Lindhout, D.A.,Allan, B.B. Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice. Nat Med, 26:1264-1270, 2020 Cited by PubMed: 32661391DOI: 10.1038/s41591-020-0945-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.91 Å) |
Structure validation
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