4JGV
| Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN | 分子名称: | 1-(3,4,5-trihydroxyphenyl)nonan-1-one, GLYCEROL, Nuclear receptor subfamily 4 group A member 1 | 著者 | Zhang, Q, Li, F, Li, A, Tian, X, Wan, W, Wan, Y, Chen, H, Xing, Y, Wu, Q, Lin, T. | 登録日 | 2013-03-04 | 公開日 | 2013-12-18 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol., 10, 2014
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6VXK
| Cryo-EM Structure of the full-length A39R/PlexinC1 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Plexin-C1, Semaphorin-like protein 139 | 著者 | Kuo, Y.-C, Chen, H, Shang, G, Uchikawa, E, Tian, H, Bai, X, Zhang, X. | 登録日 | 2020-02-22 | 公開日 | 2020-04-29 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation. Nat Commun, 11, 2020
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6X2J
| Structure of human TRPA1 in complex with agonist GNE551 | 分子名称: | 5-amino-1-[(4-bromo-2-fluorophenyl)methyl]-N-(2,5-dimethoxyphenyl)-1H-1,2,3-triazole-4-carboxamide, Transient receptor potential cation channel subfamily A member 1 | 著者 | Rohou, A, Rouge, L, Chen, H. | 登録日 | 2020-05-20 | 公開日 | 2020-11-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel. Neuron, 109, 2021
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5DAJ
| Crystal structure of NalD, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa | 分子名称: | NalD | 著者 | Chen, W.Z, Wang, D, Huang, S.Q, Hu, Q.Y, Liu, X.C, Gan, J.H, Chen, H. | 登録日 | 2015-08-20 | 公開日 | 2016-04-20 | 最終更新日 | 2023-04-12 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa Mol.Microbiol., 100, 2016
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3UBU
| Crystal structure of agkisacucetin, a GpIb-binding snaclec (snake C-type lectin) that inhibits platelet | 分子名称: | Agglucetin subunit alpha-1, Agglucetin subunit beta-2, GLYCEROL, ... | 著者 | Gao, Y, Ge, H, Chen, H, Li, H, Liu, Y, Niu, L, Teng, M. | 登録日 | 2011-10-25 | 公開日 | 2012-04-11 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Crystal structure of agkisacucetin, a Gpib-binding snake C-type lectin that inhibits platelet adhesion and aggregation. Proteins, 2012
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1OMY
| Crystal Structure of a Recombinant alpha-insect Toxin BmKaIT1 from the scorpion Buthus martensii Karsch | 分子名称: | ACETIC ACID, Alpha-neurotoxin TX12, CHLORIDE ION | 著者 | Huang, Y, Huang, Q, Chen, H, Tang, Y, Miyake, H, Kusunoki, M. | 登録日 | 2003-02-26 | 公開日 | 2003-09-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystallization and preliminary crystallographic study of rBmKalphaIT1, a recombinant alpha-insect toxin from the scorpion Buthus martensii Karsch. Acta Crystallogr.,Sect.D, 59, 2003
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5GPO
| The sensor domain structure of the zinc-responsive histidine kinase CzcS from Pseudomonas Aeruginosa | 分子名称: | SULFATE ION, Sensor protein CzcS, ZINC ION | 著者 | Wang, D, Chen, W.Z, Huang, S.Q, Liu, X.C, Hu, Q.Y, Wei, T.B, Gan, J.H, Chen, H. | 登録日 | 2016-08-03 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.701 Å) | 主引用文献 | Structural basis of Zn(II) induced metal detoxification and antibiotic resistance by histidine kinase CzcS in Pseudomonas aeruginosa PLoS Pathog., 13, 2017
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5H9T
| Crystal structure of native NalD at resolution of 2.9, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa | 分子名称: | NalD | 著者 | Chen, W.Z, Wang, D, Huang, S.Q, Hu, Q.Y, Liu, X.C, Gan, J.H, Chen, H. | 登録日 | 2015-12-29 | 公開日 | 2016-04-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa. Mol. Microbiol., 100, 2016
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8SKL
| PTP1B in complex with 182 | 分子名称: | 1,2-ETHANEDIOL, 5-[1-fluoro-3-hydroxy-7-(3-hydroxy-3-methylbutoxy)naphthalen-2-yl]-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, CHLORIDE ION, ... | 著者 | Babon, J.J, Chen, H, Tiganis, T. | 登録日 | 2023-04-20 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity. Nat Commun, 14, 2023
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1KU9
| X-ray Structure of a Methanococcus jannaschii DNA-Binding Protein: Implications for Antibiotic Resistance in Staphylococcus aureus | 分子名称: | hypothetical protein MJ223 | 著者 | Ray, S.S, Bonanno, J.B, Chen, H, de Lencastre, H, Wu, S, Tomasz, A, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2002-01-21 | 公開日 | 2002-12-25 | 最終更新日 | 2021-02-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | X-ray structure of an M. jannaschii DNA-binding protein: implications for antibiotic resistance in S.
aureus Proteins, 50, 2002
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1S9J
| X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP | 分子名称: | 5-BROMO-N-(2,3-DIHYDROXYPROPOXY)-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]BENZAMIDE, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Ohren, J.F, Chen, H, Pavlovsky, A, Whitehead, C, Yan, C, McConnell, P, Delaney, A, Dudley, D.T, Sebolt-Leopold, J, Hasemann, C.A. | 登録日 | 2004-02-04 | 公開日 | 2004-11-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat.Struct.Mol.Biol., 11, 2004
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1S9I
| X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP | 分子名称: | 5-{3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]PHENYL}-N-(2-MORPHOLIN-4-YLETHYL)-1,3,4-OXADIAZOL-2-AMINE, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 2, ... | 著者 | Ohren, J.F, Chen, H, Pavlovsky, A, Whitehead, C, Yan, C, McConnell, P, Delaney, A, Dudley, D.T, Sebolt-Leopold, J, Hasemann, C.A. | 登録日 | 2004-02-04 | 公開日 | 2004-11-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat.Struct.Mol.Biol., 11, 2004
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4MO7
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2HPV
| Crystal structure of FMN-Dependent azoreductase from Enterococcus faecalis | 分子名称: | FLAVIN MONONUCLEOTIDE, FMN-dependent NADH-azoreductase | 著者 | Liu, Z.J, Chen, L, Chen, H, Rose, J, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2006-07-17 | 公開日 | 2006-09-12 | 最終更新日 | 2017-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of Fmn-Dependent Azoreductase from Enterococcus faecalis at 2.00 A resolution To be Published
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6UZ8
| Cryo-EM structure of human TRPC6 in complex with agonist AM-0883 | 分子名称: | (5-chloro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanone, 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Bai, Y, Yu, X, Huang, X, Chen, H. | 登録日 | 2019-11-14 | 公開日 | 2020-03-18 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Structural basis for pharmacological modulation of the TRPC6 channel. Elife, 9, 2020
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6UZA
| Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473 | 分子名称: | 2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, 4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Bai, Y, Yu, X, Huang, X, Chen, H. | 登録日 | 2019-11-14 | 公開日 | 2020-03-18 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural basis for pharmacological modulation of the TRPC6 channel. Elife, 9, 2020
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5CRL
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5TIN
| Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607 | 分子名称: | (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one, CHLORIDE ION, GLYCINE, ... | 著者 | Shaffer, P.L, Huang, X, Chen, H. | 登録日 | 2016-10-03 | 公開日 | 2017-01-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Crystal Structures of Human GlyRa3 Bound to a Novel Class of Potentiators with Efficacy in a Mouse Model of Neuropathic Pain To Be Published
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5CUQ
| Identification and characterization of novel broad spectrum inhibitors of the flavivirus methyltransferase | 分子名称: | N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA, Nonstructural protein NS5 | 著者 | Brecher, B, Chen, H, Li, Z, Banavali, N.K, Jones, S.A, Zhang, J, Kramer, L.D, Li, H.M. | 登録日 | 2015-07-24 | 公開日 | 2016-02-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | 主引用文献 | Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase. Acs Infect Dis., 1, 2015
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5GPE
| Crystal structure of the transcription regulator PbrR691 from Ralstonia metallidurans CH34 in complex with Lead(II) | 分子名称: | LEAD (II) ION, Transcriptional regulator, MerR-family | 著者 | Huang, S.Q, Chen, W.Z, Wang, D, Hu, Q.Y, Liu, X.C, Gan, J.H, Chen, H. | 登録日 | 2016-08-01 | 公開日 | 2016-12-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structural Basis for the Selective Pb(II) Recognition of Metalloregulatory Protein PbrR691 Inorg Chem, 55, 2016
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2KI0
| NMR Structure of a de novo designed beta alpha beta | 分子名称: | DS119 | 著者 | Liang, H, Chen, H, Fan, K, Wei, P, Guo, X, Jin, C, Zeng, C, Tang, C, Lai, L. | 登録日 | 2009-04-18 | 公開日 | 2009-10-20 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | De novo design of a beta alpha beta motif. Angew.Chem.Int.Ed.Engl., 48, 2009
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5XXE
| Crystal structure of Poz1 and Tpz1 | 分子名称: | Protection of telomeres protein poz1, Protection of telomeres protein tpz1, SULFATE ION, ... | 著者 | Xue, J, Chen, H, Wu, J, Lei, M. | 登録日 | 2017-07-03 | 公開日 | 2017-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex. Cell Res., 27, 2017
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5XXF
| Crystal structure of Poz1, Tpz1 and Rap1 | 分子名称: | Protection of telomeres protein poz1, Protection of telomeres protein tpz1, Rap1, ... | 著者 | Xue, J, Chen, H, Wu, J, Lei, M. | 登録日 | 2017-07-03 | 公開日 | 2017-12-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex. Cell Res., 27, 2017
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8EQB
| FAM46C/BCCIPalpha/Nanobody complex | 分子名称: | Isoform 2 of BRCA2 and CDKN1A-interacting protein, Synthetic nanobody 1, Terminal nucleotidyltransferase 5C | 著者 | Liu, S, Chen, H, Yin, Y, Bai, X, Zhang, X. | 登録日 | 2022-10-07 | 公開日 | 2023-03-15 | 最終更新日 | 2023-04-26 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | Inhibition of FAM46/TENT5 activity by BCCIP alpha adopting a unique fold. Sci Adv, 9, 2023
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1KBH
| Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR | 分子名称: | CREB-BINDING PROTEIN, nuclear receptor coactivator | 著者 | Demarest, S.J, Martinez-Yamout, M, Chung, J, Chen, H, Xu, W, Dyson, H.J, Evans, R.M, Wright, P.E. | 登録日 | 2001-11-06 | 公開日 | 2002-02-06 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature, 415, 2002
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