5GW0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5gw0 by Molmil](/molmil-images/mine/5gw0) | Crystal structure of SNX16 PX-Coiled coil | 分子名称: | Sorting nexin-16 | 著者 | Xu, J, Liu, J. | 登録日 | 2016-09-08 | 公開日 | 2017-09-13 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding. Structure, 25, 2017
|
|
5GW1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5gw1 by Molmil](/molmil-images/mine/5gw1) | |
7WCY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wcy by Molmil](/molmil-images/mine/7wcy) | Crystal Structure of H-2Kb with Cryptosporidium parvum gp40/15 epitope | 分子名称: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-B alpha chain, ... | 著者 | Wang, Y.L, Gao, M.H, Zhang, L.X, Fan, S.H. | 登録日 | 2021-12-20 | 公開日 | 2022-12-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Structural Analyses of a Dominant Cryptosporidium parvum Epitope Presented by H-2K b Offer New Options To Combat Cryptosporidiosis. Mbio, 14, 2023
|
|
7KMV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7kmv by Molmil](/molmil-images/mine/7kmv) | Structure of Malaysian Banana Lectin F84T | 分子名称: | Jacalin-type lectin domain-containing protein, SULFATE ION | 著者 | Meagher, J.L, Stuckey, J.A. | 登録日 | 2020-11-03 | 公開日 | 2021-01-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Targeted disruption of pi-pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity. Sci Rep, 11, 2021
|
|
7WUI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wui by Molmil](/molmil-images/mine/7wui) | Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 | 分子名称: | Adhesion G-protein coupled receptor G2,mCherry, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Guo, S.C, He, Q.T, Xiao, P, Sun, J.P, Yu, X. | 登録日 | 2022-02-08 | 公開日 | 2022-04-27 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature, 604, 2022
|
|
7WUJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wuj by Molmil](/molmil-images/mine/7wuj) | Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 | 分子名称: | Adhesion G-protein coupled receptor G4,Uncharacterized protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Guo, S.C, Huang, S.M, He, Q.T, Xiao, P, Sun, J.P, Yu, X. | 登録日 | 2022-02-08 | 公開日 | 2022-04-27 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature, 604, 2022
|
|
8IN8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8in8 by Molmil](/molmil-images/mine/8in8) | Cryo-EM structure of the target ssDNA-bound SIR2-APAZ/Ago-gRNA quaternary complex | 分子名称: | DNA (5'-D(P*AP*AP*CP*GP*AP*CP*GP*TP*CP*TP*AP*AP*GP*AP*AP*AP*CP*CP*AP*TP*TP*AP*A)-3'), MAGNESIUM ION, Piwi domain protein, ... | 著者 | Zhang, H, Li, Z, Yu, G.M, Li, X.Z, Wang, X.S. | 登録日 | 2023-03-08 | 公開日 | 2023-07-05 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity. Cell Res., 33, 2023
|
|
8I88
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8i88 by Molmil](/molmil-images/mine/8i88) | Cryo-EM structure of TIR-APAZ/Ago-gRNA complex | 分子名称: | Piwi domain-containing protein, RNA (5'-R(P*GP*A)-3'), TIR domain-containing protein | 著者 | Zhang, H, Li, Z, Yu, G.M, Li, X.Z, Wang, X.S. | 登録日 | 2023-02-03 | 公開日 | 2023-07-05 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity. Cell Res., 33, 2023
|
|
8I87
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8i87 by Molmil](/molmil-images/mine/8i87) | Cryo-EM structure of TIR-APAZ/Ago-gRNA-DNA complex | 分子名称: | DNA (5'-D(P*TP*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*A)-3'), MAGNESIUM ION, Piwi domain-containing protein, ... | 著者 | Zhang, H, Deng, Z.Q, Yu, G.M, Li, X.Z, Wang, X.S. | 登録日 | 2023-02-03 | 公開日 | 2023-07-19 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity. Cell Res., 33, 2023
|
|
6UMI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6umi by Molmil](/molmil-images/mine/6umi) | Crystal structure of erenumab Fab-b | 分子名称: | erenumab Fab heavy chain, IgG1, erenumab Fab light chain | 著者 | Mohr, C. | 登録日 | 2019-10-09 | 公開日 | 2020-02-12 | 最終更新日 | 2020-02-26 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab). Cell Rep, 30, 2020
|
|
6UMH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6umh by Molmil](/molmil-images/mine/6umh) | Crystal structure of erenumab Fab-a | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,3-PROPANDIOL, PHOSPHATE ION, ... | 著者 | Mohr, C. | 登録日 | 2019-10-09 | 公開日 | 2020-02-12 | 最終更新日 | 2020-02-26 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab). Cell Rep, 30, 2020
|
|
6VU8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vu8 by Molmil](/molmil-images/mine/6vu8) | Structure of G-alpha-i bound to its chaperone Ric-8A | 分子名称: | Guanine nucleotide-binding protein G(i) subunit alpha-1, Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) | 著者 | Seven, A.B, Hilger, D. | 登録日 | 2020-02-14 | 公開日 | 2020-03-18 | 最終更新日 | 2020-03-25 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Structures of G alpha Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms. Cell Rep, 30, 2020
|
|
6UMG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6umg by Molmil](/molmil-images/mine/6umg) | |
6UMJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6umj by Molmil](/molmil-images/mine/6umj) | Crystal structure of erenumab Fab-c | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,3-BUTANEDIOL, erenumab Fab heavy chain, ... | 著者 | Mohr, C. | 登録日 | 2019-10-09 | 公開日 | 2020-02-12 | 最終更新日 | 2020-02-26 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab). Cell Rep, 30, 2020
|
|
6W07
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6w07 by Molmil](/molmil-images/mine/6w07) | Bruton's tyrosine kinase in complex with compound 1 | 分子名称: | DIMETHYL SULFOXIDE, Tyrosine-protein kinase BTK, ~{N}-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-propan-2-yloxy-azetidine-1-carboxamide | 著者 | Metrick, C.M, Marcotte, D.J. | 登録日 | 2020-02-29 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases. J.Med.Chem., 63, 2020
|
|
6VU5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vu5 by Molmil](/molmil-images/mine/6vu5) | Structure of G-alpha-q bound to its chaperone Ric-8A | 分子名称: | Guanine nucleotide-binding protein G(q) subunit alpha, Resistance to inhibitors of cholinesterase-8A (Ric-8A) | 著者 | Seven, A.B, Hilger, D. | 登録日 | 2020-02-14 | 公開日 | 2020-03-18 | 最終更新日 | 2020-03-25 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structures of G alpha Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms. Cell Rep, 30, 2020
|
|
6W06
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6w06 by Molmil](/molmil-images/mine/6w06) | Bruton's tyrosine kinase in complex with compound 6 | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-~{tert}-butyl-~{N}-[[4-(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl]benzamide, DIMETHYL SULFOXIDE, ... | 著者 | Metrick, C.M, Marcotte, D.J. | 登録日 | 2020-02-29 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases. J.Med.Chem., 63, 2020
|
|
6VXQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vxq by Molmil](/molmil-images/mine/6vxq) | Bruton's tyrosine kinase in complex with compound 5 | 分子名称: | DIMETHYL SULFOXIDE, N-{[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl}benzamide, Tyrosine-protein kinase BTK | 著者 | Metrick, C.M, Marcotte, D.J. | 登録日 | 2020-02-23 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases. J.Med.Chem., 63, 2020
|
|
7FC0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fc0 by Molmil](/molmil-images/mine/7fc0) | Reconstitution of MbnABC complex from Rugamonas rubra ATCC-43154 (GroupIII) | 分子名称: | FE (III) ION, Methanobactin biosynthesis cassette protein MbnB, Methanobactin biosynthesis cassette protein MbnC, ... | 著者 | Chao, D, Zhaolin, L, Shoujie, L, Li, Z, Dan, Z, Ying, J, Wei, C. | 登録日 | 2021-07-13 | 公開日 | 2022-03-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.643 Å) | 主引用文献 | Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis. Cell Res., 32, 2022
|
|
6ISU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6isu by Molmil](/molmil-images/mine/6isu) | Crystal structure of Lys27-linked di-ubiquitin in complex with its selective interacting protein UCHL3 | 分子名称: | Ubiquitin, Ubiquitin carboxyl-terminal hydrolase isozyme L3 | 著者 | Ding, S, Pan, M, Zheng, Q, Ren, Y, Hong, D. | 登録日 | 2018-11-19 | 公開日 | 2019-02-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.866 Å) | 主引用文献 | Chemical Protein Synthesis Enabled Mechanistic Studies on the Molecular Recognition of K27-linked Ubiquitin Chains. Angew. Chem. Int. Ed. Engl., 58, 2019
|
|
6KA2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ka2 by Molmil](/molmil-images/mine/6ka2) | Crystal structure of a Thebaine synthase from Papaver somniferum in complex with TBN | 分子名称: | (4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline, Thebaine synthase 2 | 著者 | Xue, J, Yu, X.J, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2019-06-20 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural insights into thebaine synthase 2 catalysis. Biochem.Biophys.Res.Commun., 529, 2020
|
|
6KA3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ka3 by Molmil](/molmil-images/mine/6ka3) | Crystal structure of a Thebaine synthase from Papaver somniferum | 分子名称: | PALMITIC ACID, SULFATE ION, Thebaine synthase 2 | 著者 | Xue, J, Yu, X.J, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2019-06-20 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.951 Å) | 主引用文献 | Structural insights into thebaine synthase 2 catalysis. Biochem.Biophys.Res.Commun., 529, 2020
|
|
2FIV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2fiv by Molmil](/molmil-images/mine/2fiv) | Crystal structure of feline immunodeficiency virus protease complexed with a substrate | 分子名称: | ACE-ALN-VAL-STA-GLU-ALN-NH2, FELINE IMMUNODEFICIENCY VIRUS PROTEASE, SULFATE ION | 著者 | Schalk-Hihi, C, Lubkowski, J, Zdanov, A, Wlodawer, A, Gustchina, A. | 登録日 | 1997-07-21 | 公開日 | 1997-11-12 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor. Biochemistry, 36, 1997
|
|
7CFS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cfs by Molmil](/molmil-images/mine/7cfs) | Cryo-EM strucutre of human acid-sensing ion channel 1a at pH 8.0 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Sun, D.M, Liu, S.L, Li, S.Y, Yang, F, Tian, C.L. | 登録日 | 2020-06-28 | 公開日 | 2020-10-21 | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | 主引用文献 | Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1. Elife, 9, 2020
|
|
7CCE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cce by Molmil](/molmil-images/mine/7cce) | |